2882-20-4

Basic information

• Product Name: 2-Methyl-3-(methylthio)pyrazine
• Synonyms: 3-Methyl-2-methylthiopyrazine;Pyrazine, 2-methyl-3-(methylthio)-;2-Methyl-3-(methylthio)pyrazine, tech., 75%;3-(METHYLTHIO)-2-METHYLPYRAZINE;2-METHYLTHIO-3-METHYL PYRAZINE FEMA NO.3208;2-METHYLMERCAPTO-3-METHYLPYRAZINE [FOR PERFUMERY] 99+%;2-Methyltio-3-methyl pyrazine;2-Methylmercapto-3-methylpyrazine [for Perfumery]
• CAS NO: 2882-20-4
• Molecular Formula: C₆H₈N₂S
• Molecular Weight: 140.21
• EINECS: 220-736-8
• Product Categories: Heterocyclic Compounds;Mono- & Polyalkylpyrazines;Pyrazines;Building Blocks;Heterocyclic Building Blocks;Pyridines ,Halogenated Heterocycles
• Mol File: 2882-20-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 213-214 °C(lit.)
• Flash Point: 210 °F
• Appearance: clear colorless liquid
• Density: 1.15 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.585(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.88±0.10(Predicted)
• CAS DataBase Reference: 2-Methyl-3-(methylthio)pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-3-(methylthio)pyrazine(2882-20-4)
• EPA Substance Registry System: 2-Methyl-3-(methylthio)pyrazine(2882-20-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 3334
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 2882-20-4(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 2882-20-4 differently. You can refer to the following data:
1. clear colorless liquid
2. 2-Methyl-3(or 5 or 6)-methylthiopyrazine has a roasted almond, hazelnut and vegetable aroma.

Preparation

From 2-methylchloropyrazine; a mixture of 2-methyl-3-methylthiopyrazine, 2-methyl-5-methylthiopyrazine, and 2-methyl-6-methylthiopyrazine is obtained.

Aroma threshold values

Detection: 4 to 60 ppb. Aroma characteristics at 1.0%: toasted popcorn, roasted almond, hazelnut, peanut and cashewnutty, with a caramellic and corn-chip nuance.

Taste threshold values

Taste characteristics at 3 to 10 ppm: nutty, roasted and earthy with coffee and corn nuances, peanut and pecan nutty, popcorn and corn chip–like with a burnt musty nuance.

InChI:InChI=1/C6H8N2S/c1-5-6(9-2)8-4-3-7-5/h3-4H,1-2H3

Upstream product

• 95-58-9 2-chloro-3-methylpyrazine 
• 74-93-1 methylthiol 
• 109-08-0 2-Methylpyrazine 
• 5188-07-8 sodium thiomethoxide 
• 5271-25-0 methyl-3 mercapto-2 pyrazine 
• 74-88-4 methyl iodide 

Downstream Products

• 56088-28-9 thieno<2,3-b>pyrazine 

Relevant articles and documents

Production method of 2-methyl-3(5 or 6)-methylthio pyrazine

The invention discloses a production method of 2-methyl-3(5 or 6)-methylthio pyrazine. The method comprises the following steps: adding solvents dichloroethane and triethylamine into a reaction kettle, sealing the reaction kettle, introducing chlorine to control the pressure in the kettle at 0.02-0.03 MPa, pumping a methylpyrazine solution into the reaction kettle by using a metering pump, controlling the temperature at 45-60 DEG C, reacting, and transferring reaction liquid(containing the chlorine)in the kettle into a dichloroethane turnover tank through filter pressing for recycling after the reaction is finished; dissolving the residual 2-methyl-3(5 or 6)-chloropyrazine hydrochloride solid in the reaction kettle with water, adjusting the neutrality, and layering to obtain a 2-methyl-3(5or 6)-chloropyrazine crude product; and dropwise adding thechloropyrazine crude product is into sodium methyl mercaptide, performing reflux reaction , and after reaction liquid is extracted, adding an aid into an organic phase to generate a hydrochloride for separating the non-pyrazine product from the product to greatly improve the aroma quality of the obtained product. The product grade is improved, and the whole production process is safe and environmentally friendly.