288251-96-7

Basic information

• Product Name: 2-Isobutyl-5-nitrobenzonitrile
• Synonyms: 2-Isobutyl-5-nitrobenzonitrile
• CAS NO: 288251-96-7
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.22518
• Mol File: 288251-96-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Isobutyl-5-nitrobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Isobutyl-5-nitrobenzonitrile(288251-96-7)
• EPA Substance Registry System: 2-Isobutyl-5-nitrobenzonitrile(288251-96-7)

Safety Data

• Hazardous Substances Data: 288251-96-7(Hazardous Substances Data)

Usage

Description

2-Isobutyl-5-nitrobenzonitrile is a chemical compound with the molecular formula C12H15N3O2. It is a yellow crystalline solid that serves as a versatile raw material in the synthesis of pharmaceuticals, agrochemicals, dyes, pigments, rubber chemicals, and other industrial products.

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-Isobutyl-5-nitrobenzonitrile is used as a raw material for the synthesis of various pharmaceuticals and agrochemicals. Its nitrile and nitro-containing structure makes it a valuable starting material for the production of a wide range of chemicals.
Used in Dye and Pigment Production:
2-Isobutyl-5-nitrobenzonitrile is used as a building block in the production of dyes and pigments, contributing to the development of diverse colorants for various applications.
Used in Rubber Chemical Manufacturing:
2-Isobutyl-5-nitrobenzonitrile is also utilized in the manufacturing of rubber chemicals, playing a role in enhancing the properties and performance of rubber products.
Safety Precautions:
2-Isobutyl-5-nitrobenzonitrile is a potential irritant to the skin, eyes, and respiratory system. Therefore, it should be handled with caution to minimize exposure and ensure the safety of workers and the environment.

Upstream product

• 84110-40-7 Dihydroxy-isobutyl-boran 
• 134604-07-2 2-bromo-5-nitrobenzonitrile 
• 72115-09-4 5-amino-2-bromo-benzonitrile 

Downstream Products

• 1344998-91-9 C₃₀H₃₆N₄O₂S 
• 1344998-08-8 5-{3-[2-ethyl-3-(4-piperidinyl)phenyl]-1,2,4-thiadiazol-5-yl}-2-(2-methylpropyl)benzonitrile 
• 1344998-06-6 1,1-dimethylethyl 4-(3-{5-[3-cyano-4-(2-methylpropyl)phenyl]-1,2,4-thiadiazol-3-yl}-2-ethylphenyl)-1-piperidinecarboxylate 
• 1344997-82-5 5-[5-(2-ethyl-3-formylphenyl)-1,3-thiazol-2-yl]-2-(2-methylpropyl)benzonitrile 
• 1344997-81-4 5-(5-bromo-1,3-thiazol-2-yl)-2-(2-methylpropyl)benzonitrile 
• 1344997-65-4 5-(3-(2-ethyl-3-formylphenyl)-1,2,4-thiadiazol-5-yl)-2-isobutylbenzonitrile 
• 1344997-64-3 5-(3-(2-ethyl-3-(2-oxoethyl)phenyl)-1,2,4-thiadiazol-5-yl)-2-isobutylbenzonitrile 
• 1344997-63-2 5-(3-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazol-5-yl)-2-(2-methylpropyl)benzonitrile 
• 1344997-62-1 5-(3-bromo-1,2,4-thiadiazol-5-yl)-2-isobutylbenzonitrile 
• 1344996-18-4 1-[(3-{5-[3-cyano-4-(2-methylpropyl)phenyl]-1,2,4-thiadiazol-3-yl}-2-ethylphenyl)methyl]-4-piperidinecarboxylic acid 
• 1334607-77-0 4-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)oxy]butanoic acid 
• 1334608-26-2 methyl N-[2-(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)ethyl]-N-methylglycinate 

Relevant articles and documents

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The present invention belongs to the technical field of chemical pharmaceuticals, and relates to a compound represented by general formula (I) or formula (II) and a preparation method thereof. The compounds are biaryl derivatives with RORγt activation activity. The biaryl derivatives disclosed in this invention can effectively activate the RORγt protein receptor, and thereby promote the differentiation of Th17 cells and increasing the production of IL-17, which can be used as an immune modulator for the treatment of various cancers or viral infection-related diseases.

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COMPOUNDS

The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.