288311-02-4

Basic information

• Product Name: 2-hydroxy-4-(4-methoxy-phenyl)-butyric acid methyl ester
• Synonyms: 2-hydroxy-4-(4-methoxy-phenyl)-butyric acid methyl ester
• CAS NO: 288311-02-4
• Molecular Weight: 224.257
• Mol File: 288311-02-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-4-(4-methoxy-phenyl)-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-4-(4-methoxy-phenyl)-butyric acid methyl ester(288311-02-4)
• EPA Substance Registry System: 2-hydroxy-4-(4-methoxy-phenyl)-butyric acid methyl ester(288311-02-4)

Safety Data

• Hazardous Substances Data: 288311-02-4(Hazardous Substances Data)

Upstream product

• 4521-28-2 4-(4-Methoxyphenyl)butyric acid 
• 20637-08-5 4-(4-methoxyphenyl)butyric acid methyl ester 

Downstream Products

• 288311-03-5 methyl 4-(4-methoxy-phenyl)-2-oxo-butyrate 

Relevant articles and documents

Regioselective intramolecular oxidation of phenols and anisoles by dioxiranes generated in situ

A novel method for regioselective oxidation of phenols and anisoles has been developed in which dioxiranes, generated in situ from ketones and Ozone, oxidize phenol derivatives in an intramolecular fashion. A series of ketones with electron-withdrawing groups, such as CF3, COOMe, and CH2Cl, were attached to phenols, anisoles, or aryl rings via a C2 or C3 methylene linker. In a homogeneous solvent system of CH3CN and H2O, oxidation of phenol derivatives 1-10 afforded spiro 2-hydroxydienones in 24-55% yields regardless of the presence of other substituents (ortho Me, meta Me or Br) on the aryl ring and the length of the linker. Experimental evidences were provided to support the mechanism that involves a regioselective π bond epoxidation of aryl rings followed by epoxide rearrangement and hemiketal formation.