288590-33-0

Basic information

• Product Name: 1,2,3-benzotriazol-1-yl-6 triphenylmethylaminohexyl carboxylate
• Synonyms: 1,2,3-benzotriazol-1-yl-6 triphenylmethylaminohexyl carboxylate
• CAS NO: 288590-33-0
• Molecular Weight: 490.605
• Mol File: 288590-33-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,2,3-benzotriazol-1-yl-6 triphenylmethylaminohexyl carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3-benzotriazol-1-yl-6 triphenylmethylaminohexyl carboxylate(288590-33-0)
• EPA Substance Registry System: 1,2,3-benzotriazol-1-yl-6 triphenylmethylaminohexyl carboxylate(288590-33-0)

Safety Data

• Hazardous Substances Data: 288590-33-0(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 3633-17-8 ethyl 6-aminocaproate hydrochloride 
• 2592-95-2 benzotriazol-1-ol 
• 5612-13-5 6-(triphenylmethylamino)hexanoic acid 
• 60-32-2 6-aminohexanoic acid 
• 228110-68-7 ethyl 6-triphenylmethylaminohexanoic acid 

Downstream Products

• 288590-35-2 C₄₄H₄₂N₁₀O₇S₄ 
• 288590-46-5 C₄₆H₄₇N₁₁O₅S₄ 
• 288590-34-1 C₅₈H₅₉N₇O₃S₂ 
• 288590-42-1 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid 
• 288590-45-4 C₄₂H₄₅N₉O₄S₃ 
• 288590-49-8 C₃₈H₃₆N₈O₄S₃ 
• 288590-44-3 C₃₈H₄₃N₇O₃S₂ 
• 288590-48-7 C₃₄H₃₄N₆O₃S₂ 
• 288590-43-2 2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carboxylic acid (3-dimethylamino-propyl)-amide 
• 288590-47-6 2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carboxylic acid methylamide 
• 288590-41-0 2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carboxylic acid 
• 288590-40-9 2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carboxylic acid 
• 288590-39-6 2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carboxylic acid 
• 228110-76-7 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

Inhibition of HIV-1 integrase-catalysed reaction by new DNA minor groove ligands: The oligo-1,3-thiazolecarboxamide derivatives

Human immunodeficiency virus type 1 (HIV-1) integrase (IN) is an essential enzyme in the life cycle of the retrovirus, responsible for catalysing the insertion of the viral genome into the host cell chromosome. For this reason it provides an attractive target for antiviral drug design. We synthesized a series of novel thiazole (Tz)-containing oligopeptides (TCOs; oligo-1,3-thiazolecarboxamides), specifically interacting within the minor groove of DNA. The oligocarboxamide derivatives contained 1-4 Tz rings and different N- and C-terminal groups. The effect of these oligocarboxamides on the HIV-1 IN-catalysed reaction was investigated. Some of the compounds were able to inhibit the reaction. The inhibitory effect of the TCOs increased with the number of Tz units. The structure of various additional positively and/or negatively charged groups attached to the N- and C-termini of TCOs had a pronounced effect on their interaction with the DNA substrate complexed to IN. Modified TCOs having a better affinity for this complex should provide a rationale for the design of drugs targeting the integration step. (C) 2000 Editions scientifiques et medicales Elsevier SAS.