28862-78-4Relevant articles and documents
A PROCESS FOR PREPARING DIAZABICYCLO[3.3.1] NONANE COMPOUNDS
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Page/Page column 14-15, (2008/12/07)
The invention is a process for preparing a diazabicyclo compound of formula (I) process for preparing a diazabicyclo compound of formula (I):where X is selected from the group consisting of hydrogen, C1-C6 alkoxycarbonyl, and carbobenzyloxy; R6 is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, and benzyl; and R9, R 10, and R11 are independently selected from the group consisting of hydrogen, halogen, and C1-C6 alkyl. wherein the process involves cyclizing I-I, formula (II).
Matrix metalloproteinase inhibitors containing a (carboxyalkyl)amino zinc ligand: Modification of the P1 and P2' residues
Brown,Brown,Bickett,Chambers,Davies,Deaton,Drewry,Foley,McElroy,Gregson,McGeehan,Myers,Norton,Salovich,Schoenen,Ward
, p. 674 - 688 (2007/10/02)
Systematic modification of the presumed P1 side chain in a series of (carboxyalkyl)amino-based inhibitors of matrix metalloproteinases enabled identification of the 2-(1,3-dihydro-1,3-dioxo-2H-benz[f]isoindol-2-yl)ethyl group as a preferred substituent imparting potent inhibition of the enzymes collagenase and gelatinase. It was subsequently found that the P2'-P3' residues in this series could be replaced by small non-peptide residues, while maintaining inhibitory potency. The imide group in this series of compounds can undergo autocatalytic hydrolysis under neutral conditions.
ENANTIOSPECIFIC SYNTHESIS OF A CHIRAL CARBAPENEM PRECURSOR FROM (R)-ASPARTIC ACID
Pellicciari, Roberto,Natalini, Benedetto,Ursini, Antonella
, p. 607 - 608 (2007/10/02)
A short enantiospecific preparation of a key intermediate to carbapenem antibiotics with (R)-aspartic acid as chiral educt is described.
