28874-46-6

Basic information

• Product Name: 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylicacid, (1R,2S,3R,4S)-rel-
• Synonyms: 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylicacid, exo,exo- (8CI); 7-Oxabicyclo[2.2.1]heptane-2,3-exo-cis-dicarboxylic acid
• CAS NO: 28874-46-6
• Molecular Formula: C8H10 O5
• Molecular Weight: 186.164
• Mol File: 28874-46-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 128-131 °C
• Boiling Point: 447.8±40.0 °C(Predicted)
• Density: 1.541±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylicacid, (1R,2S,3R,4S)-rel-(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylicacid, (1R,2S,3R,4S)-rel-(28874-46-6)
• EPA Substance Registry System: 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylicacid, (1R,2S,3R,4S)-rel-(28874-46-6)

Safety Data

• Hazardous Substances Data: 28874-46-6(Hazardous Substances Data)

Upstream product

• 1829-60-3 dimethyl 7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate 
• 81486-09-1 (2-endo,3-exo)-7-oxabicyclo<2.2.1>hept-5-ene-2,3-bis(carbonyl chloride) 
• 5629-08-3 (1S,3S,4R)-7-Oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid 
• 4505-29-7 dimethyl 7-oxabicyclo<2.2.1>heptane-2β,3β-dicarboxylate 
• 3215-51-8 cis-endo-2,3-(biscarbomethoxy)-7-oxabicyclo<2.2.1>heptane 

Downstream Products

• 55423-53-5 (2-endo,3-exo)-7-oxabicyclo<2.2.1>heptane-2,3-dimethanol 
• 28871-91-2 norcantharidimide 
• 97909-51-8 (2-endo,3-exo)-7-oxabicyclo<2.2.1>heptane-2,3-dimethanol bis(4-methylbenzenesulfonate) 
• 155397-96-9 (1S,2R,5S,6S,7R)-4-benzyl-5-ethoxy-10-oxa-4-azatricyclo<5.2.1.0>decan-3-one 
• 7802-31-5 cis-4-benzyl-10-oxa-4-azatricyclo<5.2.1.0>decane-3,5-dione 
• 7577-85-7 N-(2-Chlor-benzyl)-exo-cis-7-oxa-bicyclo<2.2.1>-heptan-2,3-dicarbonimid 
• 86844-82-8 2-(2-trifluoromethyl-phenyl)-(3at,7at)-hexahydro-4r,7c-epioxido-isoindole-1,3-dione 
• 7576-40-1 2-benzhydryl-(3at,7at)-hexahydro-4r,7c-epioxido-isoindole-1,3-dione 
• 7577-88-0 2-(2,4-dichloro-benzyl)-(3at,7at)-hexahydro-4r,7c-epioxido-isoindole-1,3-dione 
• 20711-76-6 2-(2-phenoxy-ethyl)-(3at,7at)-hexahydro-4r,7c-epioxido-isoindole-1,3-dione 
• 7577-81-3 2-(1-phenyl-ethyl)-(3at,7at)-hexahydro-4r,7c-epioxido-isoindole-1,3-dione 
• 20707-38-4 2-(2-hydroxy-phenyl)-(3at,7at)-hexahydro-4r,7c-epioxido-isoindole-1,3-dione 
• 20711-66-4 N-(2-Hydroxy-propyl)-exo-cis-7-oxa-bicyclo<2.2.1>-heptan-2,3-dicarbonimid 
• 7577-89-1 2-(3,4-dichloro-benzyl)-(3at,7at)-hexahydro-4r,7c-epioxido-isoindole-1,3-dione 

Relevant articles and documents

Dual demeanour of norcantharidin derived dicarboxamides in acidic media: An insight

The hydrolytic stability of norcantharidine derived conformationally constrained diamides in acidic media is solely governed by the type of amide. Tertiary diamides underwent smooth acid catalyzed hydrolysis due to anchimeric assistance whereas other diamides were stable. This was corroborated from conformational proximity of the amide groups for anchimeric assistance based on single crystal X-ray structure analysis. Theoretical calculations on the diamide structures also predict the similar proximity of the diamides in those conformations. Thus norcantharidine based diamides could probably serve as promising systems for delayed release of certain types of drugs which possess secondary amine component as exemplified by the release of m-chlorophenylpiperazine at a pH range of 1–2.