28874-52-4

Basic information

• Product Name: 1 2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE
• Synonyms: 1 2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE;(R)-1-[(phosphonooxy)methyl]ethylene dimyristate;3-sn-Phosphatidic acid, 1,2-dimyristoyl disodium salt, L-β,γ-Dimyristoyl-α-phosphatidic acid disodium salt;[R,(+)]-1-O,2-O-Dimyristoyl-L-glycerol 3-phosphoric acid;1,2-Dimyristoyl-L-3-phosphatidylglycerol;1-O,2-O-Bis(1-oxotetradecyl)-L-glycerol 3-phosphoric acid;1-O,2-O-Dimyristoyl-3-O-phosphono-L-glycerol;1-O,2-O-Dimyristoyl-L-glycerol-3-phosphoric acid
• CAS NO: 28874-52-4
• Molecular Formula: C31H61O8P
• Molecular Weight: 592.785001
• EINECS: 249-278-7
• Mol File: 28874-52-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 664.5°Cat760mmHg
• Flash Point: 355.7°C
• Appearance: /
• Density: 1.034g/cm³
• Vapor Pressure: 2.23E-19mmHg at 25°C
• Refractive Index: 1.473
• Storage Temp.: −20°C
• CAS DataBase Reference: 1 2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE(CAS DataBase Reference)
• NIST Chemistry Reference: 1 2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE(28874-52-4)
• EPA Substance Registry System: 1 2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE(28874-52-4)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 28874-52-4(Hazardous Substances Data)

Usage

Description

1,2-Dimyristoyl-sn-glycero-3-phosphate (DMPA) is a phospholipid molecule that consists of two myristoyl fatty acid chains bound to a glycerol backbone with a phosphate group. It is a major component of cell membranes and plays a crucial role in maintaining their integrity and function. DMPA is also involved in signaling pathways and cell communication, as well as in the regulation of membrane fluidity and permeability. Additionally, DMPA has been found to have immunomodulatory and anti-inflammatory properties, making it an important molecule in the immune response. Its unique structure and functions make DMPA a key molecule in various cellular processes and a target for pharmaceutical development in the treatment of inflammatory and immune-related diseases.

Uses

Used in Pharmaceutical Development:
1,2-Dimyristoyl-sn-glycero-3-phosphate is used as a target molecule for the development of drugs aimed at treating inflammatory and immune-related diseases. Its immunomodulatory and anti-inflammatory properties make it a promising candidate for therapeutic intervention in conditions such as autoimmune disorders and chronic inflammation.
Used in Cell Membrane Research:
1,2-Dimyristoyl-sn-glycero-3-phosphate is used as a key component in the study of cell membrane structure and function. Its role in maintaining membrane integrity and its involvement in signaling pathways and cell communication make it an essential molecule for understanding cellular processes and the mechanisms underlying various diseases.
Used in the Regulation of Membrane Fluidity and Permeability:
1,2-Dimyristoyl-sn-glycero-3-phosphate is used as a regulator of membrane fluidity and permeability. Its presence in cell membranes contributes to the proper functioning of cells and the overall homeostasis of the organism.

InChI:InChI=1/C31H61O8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-30(32)37-26-27-38-31(33)29(28-39-40(34,35)36)24-22-20-18-16-14-12-10-8-6-4-2/h29H,3-28H2,1-2H3,(H2,34,35,36)

Upstream product

• 1069-82-5 1,2-di-O-myristoyl-sn-glycerol 

Downstream Products

• 18194-24-6 dimyristoylphosphatidylcholine 
• 998-07-2 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine 

Relevant articles and documents

Synthesis of Complex Phosphomonoesters via Monomeric Metaphosphate: The Phosphatidic Acids

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