289032-98-0

Basic information

• Product Name: C₁₂H₁₅FO₂
• Synonyms: C₁₂H₁₅FO₂
• CAS NO: 289032-98-0
• Molecular Weight: 210.248
• Mol File: 289032-98-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₅FO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₅FO₂(289032-98-0)
• EPA Substance Registry System: C₁₂H₁₅FO₂(289032-98-0)

Safety Data

• Hazardous Substances Data: 289032-98-0(Hazardous Substances Data)

Upstream product

• 4286-55-9 1-bromo-6-hexanol 
• 1383151-09-4 C₁₂H₁₇FO₂ 

Downstream Products

• 1383152-27-9 (2R,3R,4R,5S)-1-(6-(4-fluorophenoxy)hexyl)-2-(hydroxymethyl)piperidine-3,4,5-triol 

Relevant articles and documents

Design, synthesis, and biological evaluation of N-Alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection

We recently described the discovery of oxygenated N-alkyl deoxynojirimycin (DNJ) derivative 7 (CM-10-18) with antiviral activity against dengue virus (DENV) infection both in vitro and in vivo. This imino sugar was promising but had an EC50 against DENV in BHK cells of 6.5 μM, which limited its use in in vivo. Compound 7 presented structural opportunities for activity relationship analysis, which we exploited and report here. These structure-activity relationship studies led to analogues 2h, 2l, 3j, 3l, 3v, and 4b-4c with nanomolar antiviral activity (EC50 = 0.3-0.5 μM) against DENV infection, while maintaining low cytotoxicity (CC50 > 500 μM, SI > 1000). In male Sprague-Dawley rats, compound 3l was well tolerated at a dose up to 200 mg/kg and displayed desirable PK profiles, with significantly improved bioavailability (F = 92 α 4%).