2892-29-7

Basic information

• Product Name: 1-(3-CHLORO-4-HYDROXYPHENYL)-1-ETHANONE
• Synonyms: 1-(3-Chloro-4-hydroxyphenyl)ethan-1-one, 4-Acetyl-2-chlorophenol;3'-Chloro-4'-hydroxyacetophenone 95%;1-(3-CHLORO-4-HYDROXYPHENYL)-1-ETHANONE;1-(3-CHLORO-4-HYDROXY-PHENYL)-ETHANONE;3'-CHLORO-4'-HYDROXYACETOPHENONE;1-(3-Chloro-4-hydroxyphenyl)-1-ethanon;Ethanone, 1-(3-chloro-4-hydroxyphenyl)-
• CAS NO: 2892-29-7
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59
• Product Categories: Aromatics;Building Blocks;C7 to C8;Carbonyl Compounds;Chemical Synthesis;Ketones;Organic Building Blocks
• Mol File: 2892-29-7.mol
• Article Data: 11

Chemical Properties

• Melting Point: 86-89
• Boiling Point: 313.2 °C at 760 mmHg
• Flash Point: 143.2 °C
• Appearance: yellow powder
• Density: 1.298 g/cm³
• Vapor Pressure: 0.000275mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 6.70±0.18(Predicted)
• CAS DataBase Reference: 1-(3-CHLORO-4-HYDROXYPHENYL)-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-CHLORO-4-HYDROXYPHENYL)-1-ETHANONE(2892-29-7)
• EPA Substance Registry System: 1-(3-CHLORO-4-HYDROXYPHENYL)-1-ETHANONE(2892-29-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• RIDADR: UN 3335
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2892-29-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Powder

Preparation

Preparation by reaction of acetyl chloride on 2-chloro-phenol with aluminium chloride in refluxing carbon disulfide (98%).

InChI:InChI=1/C8H7ClO2/c1-5(10)6-2-3-8(11)7(9)4-6/h2-4,11H,1H3

Upstream product

• 4525-75-1 2-chlorophenyl acetate 
• 766-51-8 2-Chloroanisole 
• 75-36-5 acetyl chloride 
• 99-93-4 4-Hydroxyacetophenone 
• 95-57-8 2-monochlorophenol 

Downstream Products

• 133326-08-6 3'-chloro-4,4'-dihydroxy-3-methoxy-trans-chalcone 
• 37612-52-5 4-acetyl-2-chloroanisole 
• 30335-76-3 3-(p-Acetyl-o-chlorphenoxy)butanon 
• 6077-25-4 4'-Hydroxy-5'-chlor-4-methoxy-chalkon 
• 15967-29-0 4'-Hydroxy-5'-chlor-4-dimethylamino-chalkon 
• 313510-75-7 4-acetyl-2-chlorophenyl trifluoromethanesulphonate 
• 61560-88-1 4'-benzyloxy-3'-chloroacetophenone 
• 52178-97-9 ethyl 2-(4-acetyl-2-chlorophenoxy)-2-methylpropionate 
• 1449601-15-3 4-(iododecyloxy)-3-chlorobenzoic acid 
• 1437769-14-6 C₁₇H₂₄BrClO₃ 
• 1437769-13-5 4-(acryloyloxydecyloxy)-3-chlorobenzoic acid 

Relevant articles and documents

Development of pH-activatable fluorescent probes for rapid visualization of metastatic tumours and fluorescence-guided surgeryviatopical spraying

A series of pH-activatable aza-BODIPY-based fluorescent probes were developed for rapid cancer visualization and real-time fluorescence-guided surgery by harnessing topical spraying. These probes exhibited good water-solubility, a tunable pKafrom 5.0 to 7.9, and stable intense NIR emission at ～725 nm under acidic conditions.AzaB5with a pKavalue of 6.7 was able to rapidly and clearly visualize pulmonary and abdominal metastatic tumours including tiny metastases less than 2 mmviatopical spraying, further improving intraoperative fluorescence-guided resection. We believe thatAzaB5is promising as a powerful tool to rapidly delineate a broad range of malignancies and assist surgical tumour resection.

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists

Free fatty acid receptor 1 (FFA1) is a new potential drug target for the treatment of type 2 diabetes because of its role in amplifying glucose-stimulated insulin secretion in pancreatic β-cell. In the present studies, we identified phenoxyacetic acid derivative (18b) as a potent FFA1 agonist (EC50 = 62.3 nM) based on the structure of phenylpropanoic acid derivative 4p. Moreover, compound 18b could significantly improve oral glucose tolerance in ICR mice and dose-dependently reduced glucose levels in type 2 diabetic C57BL/6 mice without observation of hypoglycemic side effect. Additionally, compound 18b exhibited acceptable PK profiles. In summary, compound 18b with ideal PK profiles exhibited good activity in vitro and in vivo, and might be a promising drug candidate for the treatment of diabetes mellitus.

Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B- adrenoceptor antagonist

Unichiral 8-substituted analogues of 2-[(2-(2,6-dimethoxyphenoxy)ethyl) aminomethyl]-1,4-benzodioxane (WB4101) were synthesized and tested for binding affinity at cloned human α1a-, α1b-and α1d-adrenoreceptor (α1a/su