2895-21-8

Basic information

• Product Name: N-ISOPROPYL-2-CHLOROACETAMIDE
• Synonyms: 2-chloro-N-propan-2-yl-ethanamide;2-chloro-N-isopropylacetamide(SALTDATA: FREE);2-Chloro-N-(prop-2-yl)acetamide, N-(Chloroacetyl)isopropylamine;Acetamide, 2-chloro-N-(1-methylethyl)-;2-CHLORO-N-ISOPROPYLACETAMIDE;AKOS USSH-4110464;BUTTPARK 80\07-100;N1-ISOPROPYL-2-CHLOROACETAMIDE
• CAS NO: 2895-21-8
• Molecular Formula: C₅H₁₀ClNO
• Molecular Weight: 135.59
• EINECS: 220-775-0
• Mol File: 2895-21-8.mol
• Article Data: 30

Chemical Properties

• Melting Point: 58-60°C
• Boiling Point: 250.6°Cat760mmHg
• Flash Point: 105.4°C
• Appearance: /
• Density: 1.052g/cm³
• Vapor Pressure: 0.0215mmHg at 25°C
• Refractive Index: 1.435
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Acetone, Chloroform, Dichloromethane, DMSO, Ethyl Acetate, Methanol
• PKA: 14.08±0.46(Predicted)
• BRN: 1745034
• CAS DataBase Reference: N-ISOPROPYL-2-CHLOROACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ISOPROPYL-2-CHLOROACETAMIDE(2895-21-8)
• EPA Substance Registry System: N-ISOPROPYL-2-CHLOROACETAMIDE(2895-21-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 2895-21-8(Hazardous Substances Data)

Usage

Description

N-ISOPROPYL-2-CHLOROACETAMIDE, also known as 2-Chloro-N-isopropylacetamide, is an organic compound that serves as an intermediate in the synthesis of various chemicals. It is characterized by its chemical structure, which includes a chloro group and an isopropyl group attached to an acetamide backbone.

Uses

Used in Pesticide Detection:
N-ISOPROPYL-2-CHLOROACETAMIDE is used as an intermediate in the synthesis of Prothoate (P838810), which is an organophosphorus pesticide. It is utilized as an analyte in the analytical study of a new method for detecting multi-residue organophosphorus pesticides, contributing to the development of more efficient and accurate detection techniques in the agricultural and environmental sectors.

InChI:InChI=1/C5H10ClNO/c1-4(2)7-5(8)3-6/h4H,3H2,1-2H3,(H,7,8)

Upstream product

• 71985-57-4 2-benzenesulfonyl-2-chloro-1-isopropyl-aziridine 
• 7572-29-4 dichloroethyne 
• 75-31-0 isopropylamine 
• 71985-56-3 2-chloro-2-(2-chloro-propane-2-sulfonyl)-1-isopropyl-aziridine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 71985-71-2 N-Isopropyl α-phenylsulfonylacetamid 
• 2275-18-5 prothoate 
• 98379-84-1 N-Isopropyl-2-(4-nitro-phenoxy)-acetamide 
• 1192313-88-4 1,1-dimethylethyl 4-[(6-[4-fluoro-3-(trifluoromethyl)phenyl]-5-{2-[(1-methylethyl)amino]-2-oxoethyl}-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl)oxy]-1-piperidinecarboxylate 
• 1192313-24-8 3-[(6-(3-chlorophenyl)-5-{2-[(1-methylethyl)amino]-2-oxoethyl}-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl)oxy]propyl acetate 
• 1192313-25-9 3-{[6-(3-chlorophenyl)-4-({2-[(1-methylethyl)amino]-2-oxoethyl}oxy)pyrazolo[1,5-a]pyrazin-2-yl]oxy}propyl acetate 
• 1192313-10-2 2-[6-(3-chloro-2-fluorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt 
• 1192313-70-4 C₁₈H₁₅F₄IN₄O₂ 
• 1192313-69-1 2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-iodo-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide 
• 1421437-09-3 1,3-(bis-diisopropylphenyl)-4-(isopropylaminide)-imidazolium 
• 1569319-02-3 1,3-(bis-2,6-diisopropylphenyl)-4-(isopropylamino)-imidazolium bromide 

Relevant articles and documents

Chirality sensing and size discrimination of anions by macrotricyclic cyclen-disodium complexes

Two macrotricyclic ligands composed of two face-to-face octadentate metal chelates were synthesized. These cage-shaped disodium complexes had special recognition ability for various counter anions. Specific chiral dicarboxylates bound to the complexes within the cavity and exhibited chirality induction properties. For instance, N-Boc-Asp dianion strongly induced circular dichroism (CD) signals, but N-Boc-Glu dianion, which is one carbon longer, did not. Chirality on Na+: The first example of chirality sensing on Na+ was achieved by a macrotricyclic host composed of two octadentate cyclen-Na+ complexes. Chiral N-Boc-Asp dianions coordinated to the Na+ at the cavity, resulting in the chirality induction of the cage molecule, but N-Boc-Glu dianion, which is one carbon longer, did not.

4-Arylthieno[2,3-b]pyridine-2-carboxamides Are a New Class of Antiplasmodial Agents

Malaria causes hundreds of thousands of deaths every year, making it one of the most dangerous infectious diseases worldwide. Because the pathogens have developed resistance against most of the established anti-malarial drugs, new antiplasmodial agents are urgently needed. In analogy to similar antiplasmodial ketones, 4-arylthieno[2,3-b]pyridine-2-carboxamides were synthesized by Thorpe-Ziegler reactions. In contrast to the related ketones, these carboxamides are only weak inhibitors of the plasmodial enzyme PfGSK-3 but the compounds nevertheless show strong antiparasitic activity. The most potent representatives inhibit the pathogens with IC50values in the two-digit nanomolar range and exhibit high selectivity indices (>100).

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