2898-54-6

Basic information

• Product Name: Methanone, (3,4-dimethoxyphenyl)(4-methoxyphenyl)-
• CAS NO: 2898-54-6
• Molecular Formula: C16H16O4
• Molecular Weight: 272.301
• Mol File: 2898-54-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Methanone, (3,4-dimethoxyphenyl)(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (3,4-dimethoxyphenyl)(4-methoxyphenyl)-(2898-54-6)
• EPA Substance Registry System: Methanone, (3,4-dimethoxyphenyl)(4-methoxyphenyl)-(2898-54-6)

Safety Data

• Hazardous Substances Data: 2898-54-6(Hazardous Substances Data)

Upstream product

• 100-66-3 methoxybenzene 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 91-16-7 1,2-dimethoxybenzene 
• 100-09-4 4-methoxybenzoic acid 
• 2898-55-7 (3,4-dimethoxy-phenyl)-(4-methoxy-phenyl)-methane 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 2859-78-1 4-Bromoveratrole 
• 98-86-2 acetophenone 
• 1426391-14-1 bis[(p-anisyl)(3,4-dimethoxyphenyl)methyl] ether 
• 944682-89-7 (3,4-dimethoxyphenyl)(4-methoxyphenyl)methanol 
• 1178964-09-4 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)-1,3-dithiane 
• 263327-99-7 4,3’,4’-trimethoxystilbene 
• 100-07-2 4-methoxy-benzoyl chloride 
• 84462-03-3 4-ethoxycarbonyloxy-3-methoxy-benzoic acid 

Downstream Products

• 100-09-4 4-methoxybenzoic acid 
• 93-07-2 Veratric acid 
• 860594-06-5 (3,4-dimethoxyphenyl)(4-methoxyphenyl)methanone oxime 
• 1496524-42-5 isopropyl((2S)-1-(((3,4-dimethoxylphenyl)(4-methoxylphenyl)methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 
• 101287-65-4 (3,4-dimethoxyphenyl)(4-methoxyphenyl)methylamine 
• 1239703-11-7 2,3'-dibromo-4,4',5-trimethoxydiphenylmethanone 
• 101719-18-0 acetic acid-[4,5-dimethoxy-2-(4-methoxy-benzyl)-anilide] 
• 2898-48-8 2-amino-4,5,4'-trimethoxy-benzophenone 
• 2898-49-9 5,6-dimethoxy-3-(4-methoxy-phenyl)-benzo[c]isoxazole 
• 4254-44-8 3,4,4'-trimethoxy-thiobenzophenone 
• 2898-52-4 4,5,4'-trimethoxy-2-nitro-benzophenone 
• 2898-55-7 (3,4-dimethoxy-phenyl)-(4-methoxy-phenyl)-methane 
• 93652-35-8 1-(3,4-dimethoxy-phenyl)-1-(4-methoxy-phenyl)-ethene 

Relevant articles and documents

Selective Oxidation of Alkylarenes to the Aromatic Ketones or Benzaldehydes with Water

Here a palladium-catalyzed oxidation method for converting alkylarenes into the aromatic ketones or benzaldehydes with water as the only oxygen donor is reported. This C-H bond oxidation functionalization does not require other oxidants and hydrogen accep

One-pot synthesis of diarylmethanones through palladium-catalyzed sequential coupling and aerobic oxidation of aryl bromides with acetophenone as a latent carbonyl donor

A one-pot palladium-catalyzed synthesis of symmetrical and unsymmetrical diarylmethanones using acetophenone and aryl bromides as raw materials has been developed. In this reaction, acetophenone acts as a latent carbonyl donor and two pathways of palladium-catalyzed sequential coupling and aerobic oxidation are identified. The reaction is applicable to a spectrum of substrates and delivers the products in moderate to good yields. This method can be used for the synthesis of ketoprofen, a nonsteroidal anti-inflammatory drug, in a two-step procedure and 45% overall yield.

Iodine-catalyzed disproportionation of aryl-substituted ethers under solvent-free reaction conditions

Iodine was demonstrated to be an efficient catalyst for disproportionation of aryl-substituted ethers under solvent-free reaction conditions. Variously substituted 1,1,1′,1′-tetraaryldimethyl ethers were transformed into the corresponding diarylketone and diarylmethane derivatives. I 2-catalyzed transformation of 4-methoxyphenyl substituted ethers yielded mono- and dialkylated Friedel-Crafts products as well. Treatment of trityl alkyl and trityl benzyl ethers with a catalytic amount of iodine produced triphenylmethane and the corresponding aldehydes and ketones. The electron-donating substituents facilitated the reaction, while the electron-withdrawing groups retarded it; the difference in reactivity is not very high. Such an observation may be in favour of hydride transfer, predominantly from the less electron rich side of the ether with more stable carbocation formation. With the isotopic studies it was established that a substantial portion of the C-H bond scission took place in the rate-determining step, while the carbonyl oxygen atom originated from the starting ether, and not from the air. The transformation took place under air and under argon, and HI was not a functioning catalyst.