289891-54-9

Basic information

• Product Name: N⁴-acetyl-2'-O-[(3-bromopropoxy)methyl]-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)
• Synonyms: N⁴-acetyl-2'-O-[(3-bromopropoxy)methyl]-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)
• CAS NO: 289891-54-9
• Molecular Weight: 938.853
• Mol File: 289891-54-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N⁴-acetyl-2'-O-[(3-bromopropoxy)methyl]-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)(CAS DataBase Reference)
• NIST Chemistry Reference: N⁴-acetyl-2'-O-[(3-bromopropoxy)methyl]-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)(289891-54-9)
• EPA Substance Registry System: N⁴-acetyl-2'-O-[(3-bromopropoxy)methyl]-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)(289891-54-9)

Safety Data

• Hazardous Substances Data: 289891-54-9(Hazardous Substances Data)

Upstream product

• 121058-82-0 N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)cytidine 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 

Relevant articles and documents

Synthesis of 5'-C- and 2'-O-(bromoalkyl)-substituted ribonucleoside phosphoramidites for the post-synthetic functionalization of oligonucleotides on solid support

The preparation of building blocks for the incorporation of 6'-O-(5- bromopentyl)-substituted β-D-allofuranosylnucleosides and 2'-O-[(3- bromopropoxy)methyl]-substituted ribonucleosides into oligonucleotide sequences is presented (Schemes 1 and 2). These reactive building blocks can be modified with a variety of soft nucleophiles while the (fully protected) sequence is still attached to the solid support. As an example of this strategy, we carried out some preliminary solid-phase substitution and conjugation reactions with DNA sequences containing a 2'-O-[(3- bromopropoxy)methyl]-substituted ribonucleoside (Scheme 3) and determined the pairing properties of duplexes obtained therefrom.