28998-36-9

Basic information

• Product Name: 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
• Synonyms: 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
• CAS NO: 28998-36-9
• Molecular Formula: C₂₉H₂₄N₄O₈
• Molecular Weight: 556.52286
• Mol File: 28998-36-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 709.9°Cat760mmHg
• Flash Point: 383.1°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 5.31E-20mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one(28998-36-9)
• EPA Substance Registry System: 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one(28998-36-9)

Safety Data

• Hazardous Substances Data: 28998-36-9(Hazardous Substances Data)

Usage

Description

4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one is a complex organic compound with a unique chemical structure. It is characterized by its triazine and ribofuranosyl moieties, which are connected through a tribenzoyl group. 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one has potential applications in various fields due to its specific chemical properties and interactions with other molecules.

Uses

Used in Pharmaceutical Industry:
4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one is used as an impurity in the production of Azacytidine (A796000), a demethylating agent. It plays a crucial role in inhibiting DNA methyltransferase, which is essential for the proper functioning of the drug. 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one is particularly important in the development and manufacturing process of Azacytidine, as it can impact the drug's efficacy and safety.
Used in Research and Development:
In the field of research and development, 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one can be used as a starting material or intermediate in the synthesis of various bioactive compounds. Its unique structure allows for further modification and functionalization, making it a valuable tool for the development of new drugs and therapeutic agents.
Used in Quality Control and Analysis:
4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one can also be employed in quality control and analytical processes related to the pharmaceutical industry. Its presence in Azacytidine production can be monitored and controlled to ensure the purity and potency of the final product. 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one can serve as a reference standard for the development of analytical methods and the validation of testing procedures.

InChI:InChI=1/C29H24N4O8/c30-28-31-17-33(29(37)32-28)24-23(41-27(36)20-14-8-3-9-15-20)22(40-26(35)19-12-6-2-7-13-19)21(39-24)16-38-25(34)18-10-4-1-5-11-18/h1-15,17,21-24H,16H2,(H2,30,32,37)

Upstream product

• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 52523-35-0 2-(trimethylsilylamino)-4-(trimethylsilyloxy)-s-triazine 

Downstream Products

• 320-67-2 5-azacytidine 
• 65370-91-4 6-amino-3-β-D-ribofuranosyl-1,3,5-triazine-2,4(1H,3H)-dione 
• 126193-22-4 6-amino-3-(2,3,5-tri-O-benzoyl-β-D-ribosyl)-1,3,5-triazine-2,4(1H,3H)-dione 

Relevant articles and documents

Synthesis, Hydrolytic Stability, and Antileukemic Activity of Azacytidine Nucleoside Analogs

New azacytidine nucleoside analogs with modified carbohydrate moieties were synthesized. Screening identified a highly active 2′-fluoro-containing azacytidine analog that could potentially be of interest as an agent for treating acute myelogenous leukemia and myelodysplastic syndrome.