29030-57-7Relevant articles and documents
Schmidt reaction of ketones in dme solution in a continuous-flow microreactor
Chen, Yuesu,Liu, Binjie,Liu, Xiaofeng,Yang, Yongtai,Ling, Yun,Jia, Yu
supporting information, p. 1589 - 1592 (2015/02/19)
The Schmidt reaction, the treatment with hydroazoic acid in the presence of a strong acid, converts ketones to amides directly and has been broadly applied in organic synthesis. In this communication, the Schmidt reaction of ketones was carried out in DME solution in a continuous-flow microreactor and gave the amide products. The enclosed small-volume feature of the microreactor made this reaction safe, fast, and cost-effective.