290362-27-5

Basic information

• Product Name: 3-hydroxy-3-phenylpropyl methanesulfonate
• Synonyms: 3-hydroxy-3-phenylpropyl methanesulfonate
• CAS NO: 290362-27-5
• Molecular Weight: 230.285
• Mol File: 290362-27-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-3-phenylpropyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-phenylpropyl methanesulfonate(290362-27-5)
• EPA Substance Registry System: 3-hydroxy-3-phenylpropyl methanesulfonate(290362-27-5)

Safety Data

• Hazardous Substances Data: 290362-27-5(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 4850-49-1 1-phenyl-1,3-propanediol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 906532-26-1 3-(N,N-diisopropylamino)-1-phenylpropan-1-ol 
• 260389-90-0 5-hydroxymethyl tolterodine 
• 200801-70-3 RS-N,N-diisopropyl-3-(2-hydroxy-5-(hydroxymethyl)phenyl)-3-phenylpropylamine 
• 207679-81-0 (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol 
• 42142-52-9 3-methylamino-1-phenylpropan-1-ol 
• 14593-04-5 3-amino-3-phenyl-1-propanol 

Relevant articles and documents

Convenient Continuous Flow Synthesis of N-Methyl Secondary Amines from Alkyl Mesylates and Epoxides

The first continuous flow process was developed to synthesize N-methyl secondary amines from alkyl mesylates and epoxides via a nucleophilic substitution using aqueous methylamine. A variety of N-methyl secondary amines were produced in good to excellent yields, including a number of bioactive compounds or their precursors. Up to 10.6 g (88% yield) of an N-methyl secondary amine was produced in 140 min process time. The amination procedure included an in-line workup, and the starting mesylate material was also produced in continuous flow from the corresponding alcohol. Finally, an in-line process combining the mesylate synthesis and nucleophilic substitution was developed.