290366-76-6

Basic information

• Product Name: ethyl 3-(2-methoxyphenyl)-4-nitrobutanoate
• Synonyms: ethyl 3-(2-methoxyphenyl)-4-nitrobutanoate
• CAS NO: 290366-76-6
• Molecular Weight: 267.282
• Mol File: 290366-76-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 3-(2-methoxyphenyl)-4-nitrobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(2-methoxyphenyl)-4-nitrobutanoate(290366-76-6)
• EPA Substance Registry System: ethyl 3-(2-methoxyphenyl)-4-nitrobutanoate(290366-76-6)

Safety Data

• Hazardous Substances Data: 290366-76-6(Hazardous Substances Data)

Upstream product

• 135-02-4 ortho-anisaldehyde 
• 75-52-5 nitromethane 
• 33877-05-3 ethyl 3-(2-methoxyphenyl)acrylate 

Relevant articles and documents

Asymmetric synthesis of piperidines using the nitro-Mannich reaction☆

A method for the synthesis of functionalized piperidines containing 3 contiguous stereocentres in the 2-,3- and 4- positions uses a diastereoselective nitro-Mannich to control stereochemistry. The nitro-Mannich reaction between a β-aryl/heteroaryl substituted nitroalkanes and glyoxylate imine provides β-nitro-amines with good selectivity (70:30 to >95:5) for the syn, anti-diastereoisomers. Reductive cyclisation with BF3.OEt2 and Et3SiH gave, after purification, stereochemically pure piperidines in 19–57% yield for ten examples with different 4-aryl/heteroaryl substituents.