2908-71-6

Basic information

• Product Name: 4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, monohydrobromide
• Synonyms: 4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, monohydrobromide;4-Amino-5-(bromomethyl)-2-methylpyrimidine Hydrobromide;5-(Bromomethyl)-2-methylpyrimidin-4-amine hydrobromide, >=97%
• CAS NO: 2908-71-6
• Molecular Formula: 2BrH*C₆H₈BrN₃
• Molecular Weight: 282.96
• Product Categories: Amines;Heterocycles;Protein Kinase Inhibitors and Activators
• Mol File: 2908-71-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 192-193 °C
• Boiling Point: 339.9 °C at 760 mmHg
• Flash Point: 159.4 °C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, monohydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, monohydrobromide(2908-71-6)
• EPA Substance Registry System: 4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, monohydrobromide(2908-71-6)

Safety Data

• Hazardous Substances Data: 2908-71-6(Hazardous Substances Data)

Usage

Uses

A pyrimidine derivative as G protein-coupled receptor kinase (GRK) inhibitor.

Upstream product

• 769-82-4 4-amino-5-methoxymethyl-2-methylpyrimidine 
• 749835-80-1 2-methyl-5-ethoxymethyl-6-chloropyrimidine 
• 73-66-5 5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine 

Downstream Products

• 92-35-3 thiochrome 
• 102787-95-1 5-ethoxycarbonyl-3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-4-methyl-thiazolium; chloride-hydrochloride 
• 5423-74-5 N⁴,N⁴-diethyl-N¹-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-1-methyl-butanediyldiamine 
• 25626-41-9 4-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-6-methyl-2-phenyl-4H-[1,3,4]thiadiazin-5-one 
• 25626-38-4 4-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-6-phenyl-4H-[1,3,4]thiadiazin-5-one 
• 27512-93-2 phosphoric acid dimethyl ester 1-(6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-ethyl ester 
• 28742-12-3 1-ethyl-3-[2-methyl-5-(3-methyl-5-oxo-6-phenyl-5,6-dihydro-[1,2,4]thiadiazin-4-ylmethyl)-pyrimidin-4-yl]-urea 
• 28742-07-6 4-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-3-methyl-6-phenyl-4H-[1,2,4]thiadiazin-5-one 
• 13100-57-7 2-methyl-4-amino-5-hydroxymethylpyrimidine hydrochloride 
• 14707-32-5 2-(1-Hydroxyethyl)-thiamin hydrochloride 
• 532-40-1 thiamine monophosphate chloride 
• 154-87-0 thiamine diphosphate 
• 27497-92-3 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-phenyl-[1,3,4]thiadiazolium; bromide hydrobromide 
• 1886-29-9 N-(2-methyl-4-amino-5-pyrimidinyl)methylaniline 

Relevant articles and documents

RADIOISOTOPE 18F SUBSTITUTED THIAMINE, AND SYNTHESIS METHOD AND USE THEREOF

The present invention discloses a radioisotope 18F substituted thiamine, synthesis method, and use thereof in small animal PET/CT imaging. The radioisotope 18F substituted thiamine has a structure of The synthesis method comprises radiochemical synthesis by using existing precursors. In the present invention, the hydroxyl in the hydroxyethyl on the thiazole cycle of thiamine is replaced by radioisotope 18F, to prepare a PET tracer. The radioisotope 18F substituted thiamine of the present invention successfully enters the brains of various strains of mice, and the uptake in the brains of thiamine-deficient mice is obviously greater than that in normal control. The present invention is useful in the preparation of a brain imaging tracer for clinical trials of Alzheimer's disease and tumors.