291296-62-3Relevant articles and documents
Superoxide dismutase activity of ternary copper complexes of sulfathiazole and imidazole derivatives. Synthesis and properties of [CuL2(R-Him)2] [HL = 4-amino-N-(thiazol-2-yl)benzenesulfonamide, R-Him = 4-methylimidazole, 4,4-dimethylimidazoline or 1,2-dimethylimidazole]. Crystal structure of [CuL2(4,4-dimethylimidazoline)2]
Casanova, Javier,Alzuet, Gloria,Ferrer, Sacramento,Latorre, Julio,Antonio Ramírez, Jose,Borrás, Joaquín
, p. 170 - 177 (2000)
New ternary copper(II) complexes of sulfathiazole (4-amino-N-(thiazol-2-yl)benzenesulfonamide)(HL) and methyl imidazole derivatives have been synthesised and characterised. The crystal structure of the complex [CuL2(4,4-dmHim)2] (1) [4,4-dmHim = 4,4-dimethylimidazoline] has been determined. The copper centre has a quasi regular square planar environment with Cu-nitrogen bond lengths ranging from 1.952 to 2.010 ?. From the spectroscopic properties of the complexes [CuL2(1,2-dmHim)2] (2) [1,2-dmHim = 1,2-dimethylimidazole] and [CuL2(4-mHim)2] (3) [4-mHim = 4-methylimidazole] a distorted tetragonal octahedral geometry is deduced. The compounds showed SOD mimetic activity in fact, a low concentration of the complexes catalyses the dismutation of superoxide at biological pH. This SOD activity is correlated with their structural properties. Using Extended Huckel Molecular Orbital Calculations the one-electron energy levels of the CuN4 chromophore in complex 1 are reported and correlated with the data of the CuN6 and CuN5 chromophores of the previously reported [CuL2(Him)2]·MeOH and [CuL2(mim)2]·H2O compounds. In addition, the influence of the geometry distortion on the composition and energy of the molecular orbitals is described using idealised models. (C) 2000 Elsevier Science S.A.