29144-31-8Relevant articles and documents
On the formation of a side product with hexahydroaporphine-like structure in the Grewe cyclization of dextromethorphan
Zhao, Qiao,Zhao, Kai,Wu, Sheng-ying,Tian, Bo-xue,Eriksson, Leif A.,Wang, Li-min,An, Na,Long, Zhong-zhu,Cai, Shui-hong
, p. 1689 - 1708 (2017/02/15)
Factors leading to the formation of a hexahydroaporphine-like cyclizing side product were studied systematically for the first time and the ratio of this side product was controlled effectively. To understand better the electronic effect of substrates on the formation of side products, different 1-benzyloctahydroisoquinolines with substituted groups on nitrogen or benzene ring were compared. A plausible mechanism of cyclizing reaction was proposed, and key intermediates as well as transition states were analyzed using DFT calculations.
COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY DISORDERS
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, (2013/12/03)
The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of respiratory disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of cough caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common cold), as well as those resulting from inhaled particle irritants, upper respiratory infections, (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis, neuropathic pain and pain associated with fibromyalgia.
New efficient methods for the synthesis and in-situ preparation of ruthenium(II) complexes of atropisomeric diphosphines and their application in asymmetric catalytic hydrogenations
Heiser,Broger,Crameri
, p. 51 - 62 (2007/12/18)
A new synthetically useful method for the synthesis of the diphosphine ruthenium dicarboxylato complexes (P-P)Ru(O2CR)2(R= CF3 and CH3) is presented, which uses the easily accessible complex (COD)2Ru2(μ-O2CCF3)4 as starting material. This complex as well as (COD)(Ru(ηO2CCH3)2 and (COD)2Ru2Cl4(NCCH3) have been shown to be suitable precursor complexes for the in-situ preparation of ruthenium(II) dicarboxylato and dichloro complexes of atropisomeric diphosphines, respectively. The high efficacy of the preformed and in-situ generated ruthenium complexes as precatalysts is demonstrated in asymmetric hydrogenations of allylic alcohols, enamides, and a β-keto ester.