291761-03-0Relevant articles and documents
The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.
Tucker, Thomas J,Abrams, Marc T,Buser, Carolyn A,Davide, Joseph P,Ellis-Hutchings, Michelle,Fernandes, Christine,Gibbs, Jackson B,Graham, Samuel L,Hartman, George D,Huber, Hans E,Liu, Dongming,Lobell, Robert B,Lumma, William C,Robinson, Ronald G,Sisko, John T,Smith, Anthony M
, p. 2027 - 2030 (2007/10/03)
We have prepared a series of potent, dual inhibitors of the prenyl transferases farnesyl protein transferase (FPTase) and geranyl-geranyl protein transferase I (GGPTase). The compounds were shown to possess potent activity against both enzymes in cell cul
