291778-48-8

Basic information

• Product Name: benzyl (4S,5R)-5-hydroxy-4-(propan-2-yl)-5-(trifluoromethyl)-1,3-oxazolidine-3-carboxylate
• CAS NO: 291778-48-8
• Molecular Weight: 333.307
• Mol File: 291778-48-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl (4S,5R)-5-hydroxy-4-(propan-2-yl)-5-(trifluoromethyl)-1,3-oxazolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl (4S,5R)-5-hydroxy-4-(propan-2-yl)-5-(trifluoromethyl)-1,3-oxazolidine-3-carboxylate(291778-48-8)
• EPA Substance Registry System: benzyl (4S,5R)-5-hydroxy-4-(propan-2-yl)-5-(trifluoromethyl)-1,3-oxazolidine-3-carboxylate(291778-48-8)

Safety Data

• Hazardous Substances Data: 291778-48-8(Hazardous Substances Data)

Upstream product

• 66866-64-6 (4S)-4-isopropyl-5-oxo-1,3-oxazolidine-3-carboxylic acid benzyl ester 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 1247868-81-0 C₁₅H₂₀F₃NO₄ 

Relevant articles and documents

Stereoselective synthesis of chiral β-amino trifluoromethyl alcohol: Development of a manufacturing process for a key intermediate in the production of a novel elastase inhibitor, AE-3763

We have successfully synthesized chiral β-amino trifluoromethyl alcohol (2S,3S)-7a, which is a key intermediate in the production of AE-3763, by stereoselective reduction of N-Cbz-protected 5-hydroxy-5-(trifluoromethyl)- 1,3-oxazolidine 4 prepared from L-valine in 3 steps followed by alkaline hydrolysis. This new method can be applied to the industrial-scale synthesis of AE-3763.