2919-23-5

Basic information

• Product Name: Cyclobutanol
• Synonyms: HYDROXYCYCLOBUTANE;CYCLOBUTANOL;CYCLOBUTANOL, 99+%;Cyclobutanol, 98+%;1-Cyclobutanol;Cyclobutane-1-ol;CyclobutanolDISC when stock is gone;cyclobutanol(SALTDATA: FREE)
• CAS NO: 2919-23-5
• Molecular Formula: C₄H₈O
• Molecular Weight: 72.11
• EINECS: 220-858-1
• Product Categories: API intermediates;Cyclobutanes & Cyclobutenes;Simple 4-Membered Ring Compounds;Alcohols;C2 to C6;Oxygen Compounds
• Mol File: 2919-23-5.mol
• Article Data: 37

Chemical Properties

• Melting Point: 262-263 °C
• Boiling Point: 123 °C733 mm Hg(lit.)
• Flash Point: 70 °F
• Appearance: Clear colorless/Liquid
• Density: 0.921 g/mL at 25 °C(lit.)
• Vapor Pressure: 6.1mmHg at 25°C
• Refractive Index: n20/D 1.435(lit.)
• Storage Temp.: Flammables area
• Solubility: Partly soluble.
• PKA: 15.31±0.20(Predicted)
• BRN: 2035937
• CAS DataBase Reference: Cyclobutanol(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutanol(2919-23-5)
• EPA Substance Registry System: Cyclobutanol(2919-23-5)

Safety Data

• Statements: 10
• Safety Statements: 23-24/25-16
• RIDADR: UN 1987 3/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 2919-23-5(Hazardous Substances Data)

Usage

Description

Cyclobutanol is a clear, colorless liquid with synthetic applications in various chemical reactions, particularly in gold-catalyzed ring expansions. It also plays a role in the development of novel types of transition metal-catalyzed cascade reactions that utilize small ring systems.

Uses

Used in Chemical Synthesis:
Cyclobutanol is used as a synthetic compound for gold-catalyzed ring expansions, which are important in the development of new chemical structures and materials.
Used in Catalyst Development:
Cyclobutanol is used as a component in the development of novel transition metal-catalyzed cascade reactions. These reactions involve small ring systems and are crucial for creating complex molecular structures with potential applications in various industries.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, Cyclobutanol's synthetic applications and its involvement in the development of new chemical reactions could potentially make it a valuable compound in the pharmaceutical industry for the creation of new drugs and drug delivery systems.
Used in Material Science:
Cyclobutanol's role in chemical synthesis and the development of novel reactions may also make it useful in material science, where new materials with specific properties are constantly being sought after for various applications, such as electronics, aerospace, and automotive industries.

InChI:InChI=1/C4H8O/c5-4-2-1-3-4/h4-5H,1-3H2

Upstream product

• 13287-42-8 (2-bromoethyl)oxirane 
• 2516-33-8 Cyclopropylmethanol 
• 287-23-0 cyclobutane 
• 6802-75-1 diethyl isopropylidenemalonate 
• 123-72-8 butyraldehyde 
• 17085-88-0 diethyl propylidenemalonate 
• 624-49-7 dimethylfumarate 
• 495-40-9 propiophenone 
• 7732-18-5 water 
• 5911-08-0 chloro(cyclopropyl)methane 
• 1191-95-3 cyclobutanone 
• 67-63-0 isopropyl alcohol 
• 7252-53-1 (aminomethyl)cyclopropane hydrochloride 
• 6291-01-6 cyclobutanamine hydrochloride 

Downstream Products

• 25714-71-0 4-hydroxybutyraldehyde 
• 675-56-9 homoallyl fluoride 
• 666-16-0 cyclobutyl fluoride 
• 4399-47-7 Bromocyclobutane 
• 1191-95-3 cyclobutanone 
• 108-93-0 cyclohexanol 
• 36833-02-0 Cyclobutyl-p-methoxybenzenesulfonate 
• 36832-98-1 cyclobutyl p-nitrobenzenesulfonate 
• 927-73-1 3-butenyl chloride 
• 219624-04-1 2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester 4-cyclobutyl ester 
• 67-63-0 isopropyl alcohol 
• 276697-74-6 cyclobutyl (4-nitrophenyl) carbonate 
• 475149-33-8 1-cyclobutyl-4-[(4-ethylphenyl)methyl]-5-trifluoromethyl-3-O-t-butyldimethylsilyl-1H-pyrazole 
• 582333-29-7 acetic acid 3-cyclobutoxy-phenyl ester 

Relevant articles and documents

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Thermal molecular beam matrix spectroscopy of cyclobutanol: temperature dependence of lineshapes and the conformation problem

Thermal molecular beam spectra of cyclobutanol isolated in Ar and Xe matrices and the temperature dependence of the ν(OH) Raman line are reported.Six matrix bands are shown by lineshape analysis to consist of 4-6 components which systematically decrease and increase with increasing temperature of the molecular beam source.Data on lineshape parameters and relative intensities are reported.Likewise the ν(OH) Raman band is shown to consist of four components which behave with respect to temperature dependence analogously to the matrix bands.The results will be discussed in terms of two models.

Ru-Photoredox-Catalyzed Decarboxylative Oxygenation of Aliphatic Carboxylic Acids through N-(acyloxy)phthalimide

Decarboxylative aminoxylation of aliphatic carboxylic acid derivatives with (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) in the presence of ruthenium photoredox catalysis is reported. The key transformation entails a highly efficient photoredox catalytic cycle using Hantzsch ester as a reductant. The ensuing alkoxyamine can be readily converted to the corresponding alcohol in one pot, representing an alternative approach to access aliphatic alcohols under photoredox conditions.

Synthesis and kinetic regularities of the thermal decomposition of new hydrotrioxides of cyclic alcohols

Cyclic hydrotrioxides were synthesized by low-temperature (?78 °C) ozonolysis of a series of cyclic alcohols and identified using 1H NMR spectra. The kinetic regularities of the thermal decomposition of the synthesized hydrotrioxides were studied. The experimental proof of the induced decomposition of alcohol hydrotrioxides was obtained for the first time using cyclohexanol hydrotrioxide as an example. The influence of cyclic substituents on the thermal stability of the hydrotrioxides is shown.