29199-11-9Relevant articles and documents
Synthesis, characterization and supramolecular building motifs of substituted salphen- and thiasalphen–metal complexes
Kumar, Nitesh,Asatkar, Ashish K.,Panda, Snigdha,Zade, Sanjio S.
, p. 718 - 728 (2016)
Two new series of substituted salphen-metal complexes and thiasalphen–metal complexes have been synthesized. The fluorine substituted salphen-metal complexes (5, 6 and 7) were prepared by the coordination of ligand 4 (obtained by the reaction of 4,5-difluorosalicylaldehyde with o-phenylenediamine) with Ni(II), Cu(II) and Zn(II) ions, respectively. The thiasalphen–metal complexes (8, 9 and 10) were prepared strategically following the unique route of the in situ reduction of bis(o-formylphenyl)disulfide to mercaptobenzaldehyde then complexation with Ni(II), Cu(II) and Zn(II) ions, followed by Schiff base coupling with o-phenylenediamine, in a single pot. The products were characterized by elemental analysis, ESI-MS, FT-IR and1H/13C NMR spectroscopy. The structures of 4, 5, 6, 9 and 10 were established by single crystal X-ray analysis. The various non-bonding interactions resulted in fascinating supramolecular building motifs. The photophysical and electrochemical properties (band gaps, HOMO?LUMO energies) of all the six complexes were studied by UV–Vis spectroscopy and cyclic voltammetry. The optical band gaps were found to be in the range 2.31–2.79?eV.
Comparative Study of Aluminum Complexes Bearing N,O- and N,S-Schiff Base in Ring-Opening Polymerization of ε-Caprolactone and l -Lactide
Chang, Meng-Chih,Lu, Wei-Yi,Chang, Heng-Yi,Lai, Yi-Chun,Chiang, Michael Y.,Chen, Hsing-Yin,Chen, Hsuan-Ying
, p. 11292 - 11298 (2015)
A series of Al complexes bearing Schiff base and thio-Schiff base ligands were synthesized, and their application for the ring-opening polymerization of ε-caprolactone (CL) and l-lactide (LA) was studied. It was found that steric effects of the ligands caused higher polymerization rate and most importantly the Al complexes with N,S-Schiff base showed significantly higher polymerization rate than Al complexes with N,O-Schiff base (5-12-fold for CL polymerization and 2-7-fold for LA polymerization). The reaction mechanism of CL polymerization was investigated by density functional theory (DFT). The calculations predicted a lower activation energy for a process involved with an Al complex bearing an N,S-Schiff base ligand (17.6 kcal/mol) than for that of an Al complex bearing an N,O-Schiff base ligand (19.0 kcal/mol), and this magnitude of activation energy reduction is comparable to the magnitude of rate enhancement observed in the experiment. The reduction of activation energy was attributed to the catalyst-substrate destabilization effect. Using a sulfur-containing ligand to decrease the activation energy in the ring-opening polymerization process may be a new strategy to design a new Al complex with high catalytic activity.
Synthesis and evaluation of antileishmanial and cytotoxic activity of benzothiopyrane derivatives
Ortiz, Cristian,Echeverri, Fernando,Robledo, Sara,Lanari, Daniela,Curini, Massimo,Qui?ones, Wiston,Vargas, Esteban
, (2020)
In continuation of our efforts to identify promising antileishmanial agents based on the chroman scaffold, we synthesized several substituted 2H-thiochroman derivatives, including thiochromenes, thichromanones and hydrazones substituted in C-2 or C-3 with carbonyl or carboxyl groups. Thirty-two compounds were thus obtained, characterized, and evaluated against intracellular amastigotes of Leishmania (V) panamensis. Twelve compounds were active, with EC50 values lower than 40 μM, but only four compounds displayed the highest antileishmanial activity, with EC50 values below 10 μM; these all compounds possess a good Selectivity Index > 2.6. Although two active compounds were thiochromenes, a clear structure-activity relationship was not detected since each active compound has a different substitution pattern.
DEPALMITOYLATING COMPOSITIONS AND THE USE THEREOF
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Paragraph 0359; 0369; 0371, (2021/02/19)
Disclosed herein, inter alia, are depalmitoylating compounds, compositions, and methods of use thereof.
Substituted Benzothietes: Synthesis and a Quantum Chemical Investigation of Their Cycloreversion Properties
Ahlburg, Nils L.,Velarde, Andres R.,Kieber-Emmons, Matthew T.,Jones, Peter G.,Werz, Daniel B.
supporting information, p. 4255 - 4260 (2020/06/04)
A flexible synthesis for highly substituted benzothietes that does not require flash-vacuum pyrolysis was developed. This allows for the use of a number of functional groups and nonvaporizable molecules. Highly stabilized derivatives were isolated. The molecular orbital properties of various benzothietes were evaluated by density functional methods. The mechanism of the cycloreversion of the four-membered ring was compared to that of the oxygen-containing analogues.