2924-80-3

Basic information

• Product Name: ethyl 4,4,4-trifluoro-3-oxo-2-(ureidomethylidene)butanoate
• CAS NO: 2924-80-3
• Molecular Weight: 254.166
• Mol File: 2924-80-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 4,4,4-trifluoro-3-oxo-2-(ureidomethylidene)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4,4,4-trifluoro-3-oxo-2-(ureidomethylidene)butanoate(2924-80-3)
• EPA Substance Registry System: ethyl 4,4,4-trifluoro-3-oxo-2-(ureidomethylidene)butanoate(2924-80-3)

Safety Data

• Hazardous Substances Data: 2924-80-3(Hazardous Substances Data)

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 57-13-6 urea 
• 571-55-1 ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate 

Downstream Products

• 187035-79-6 ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 
• 149771-09-5 ethyl 2-amino-4-(trifluoromethyl)pyrimidine-5-carboxylate 
• 154934-97-1 ethyl 2-hydroxy-4-trifluoromethylpyrimidine-5-carboxylate 

Relevant articles and documents

Synthesis of pyrimidine derivatives based on ethyl 2-ethoxymethylidene-3- polyfluoroalkyl-3-oxopropionates: And urea

Ethyl 2-ethoxymethylidene-3-polyfluoroalkyl-3-oxopropionates under mild conditions undergo regioselective condensation with urea at the ethoxymethylidene substituent giving rise to ethyl 3-polyfluoroalkyl-3-oxo-2- (ureidomethylidene)propionates. Under more drastic conditions, the latter cyclize at the fluoroacyl fragment to form ethyl 4-polyfluoroalkyl-4-hydroxy-2- oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates.