292618-32-7 Usage
General Description
ST1481 is a novel small molecule compound that has shown inhibitory activity against multiple cancer cell lines, including breast, lung, and prostate cancer. It acts by binding to and inhibiting the activity of the enzyme squalene synthase, which is involved in the synthesis of cholesterol and other sterols. In preclinical studies, ST1481 has demonstrated promising antitumor activity, making it a potential candidate for further development as an anticancer therapy. Additionally, it has been shown to have a good safety profile in animal studies, indicating its potential for low toxicity in humans. Its unique mechanism of action and promising preclinical data position ST1481 as a promising candidate for the development of new cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 292618-32-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,2,6,1 and 8 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 292618-32:
(8*2)+(7*9)+(6*2)+(5*6)+(4*1)+(3*8)+(2*3)+(1*2)=157
157 % 10 = 7
So 292618-32-7 is a valid CAS Registry Number.
InChI:InChI=1/C25H25N3O5/c1-5-25(31)18-10-20-21-16(12-28(20)22(29)17(18)13-32-23(25)30)15(11-26-33-24(2,3)4)14-8-6-7-9-19(14)27-21/h6-11,31H,5,12-13H2,1-4H3/b26-11+/t25-/m0/s1
292618-32-7Relevant articles and documents
Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity
Dallavalle,Ferrari,Biasotti,Merlini,Penco,Gallo,Marzi,Tinti,Martinelli,Pisano,Carminati,Carenini,Beretta,Perego,De Cesare,Pratesi,Zunino
, p. 3264 - 3274 (2001)
In an attempt to synthesize potential anticancer agents acting by inhibition of topoisomerase I (Topo I) a new series of oxyiminomethyl derivatives in position 7 of camptothecin (CPT) was prepared. The synthesis relied on the condensation of 20S-CPT-7-ald
