2930-02-1

Basic information

• Product Name: 2-(p-Ethylphenoxymethyl)oxirane
• Synonyms: 2-(p-Ethylphenoxymethyl)oxirane;4-Ethylphenylglycidyl ether;[(4-Ethylphenoxy)Methyl]oxirane;1,2-Epoxy-3-(p-ethylphenoxy)propane;2,3-Epoxypropyl 4-Ethylphenyl Ether;p-Ethylphenyl Glycidyl Ether
• CAS NO: 2930-02-1
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 2930-02-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(p-Ethylphenoxymethyl)oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(p-Ethylphenoxymethyl)oxirane(2930-02-1)
• EPA Substance Registry System: 2-(p-Ethylphenoxymethyl)oxirane(2930-02-1)

Safety Data

• Hazardous Substances Data: 2930-02-1(Hazardous Substances Data)

Usage

Description

2-(p-Ethylphenoxymethyl)oxirane is an organic compound belonging to the class of epoxides. It is characterized by the presence of a three-membered oxirane ring, which is a cyclic ether with an oxygen atom and two carbon atoms. 2-(p-Ethylphenoxymethyl)oxirane has a p-ethylphenoxymethyl group attached to the second carbon of the oxirane ring, which may contribute to its specific properties and applications.

Uses

Used in Pesticide Industry:
2-(p-Ethylphenoxymethyl)oxirane is used as an active ingredient for [application reason] due to its enzyme epoxide hydrase inhibitory effects. This property makes it a potential candidate for the development of new pesticides, as it can interfere with the normal functioning of target pests, leading to their control and management in agricultural settings.

Upstream product

• 123-07-9 4-Ethylphenol 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 106-89-8 epichlorohydrin 

Downstream Products

• 437994-25-7 7,7,9,9-tetramethyl-8-[1-(4-oxiranylmethoxy-phenyl)-ethoxy]-1,4-dioxa-8-aza-spiro[4.5]decan 
• 1254940-27-6 C₂₈H₃₂N₄O₂S 

Relevant articles and documents

Synthesis and evaluation of 4-(2-hydroxypropyl)piperazin-1-yl) derivatives as Hsp90 inhibitors

We previously reported 4-(3-((6-bromonaphthalen-2-yl)oxy)-2-hydroxypropyl)-N,N-dimethylpiperazine-1-sulfonamide (1) as a novel heat shock protein 90 inhibitor with moderate activity. In our ongoing efforts for the discovery of Hsp90 modulators we undertake structural investigations on 1. Series of the titled compound were designed, synthesized and evaluated. We have found that compounds with a hydroxyl group at C-4 of the aryl ring on the piperazine moiety possess Hsp90 inhibition properties. Compound 6f with improved activity could be further developed and optimized as Hsp90 inhibitor.

Thienopyrimidines as β3-adrenoceptor agonists: Hit-to-lead optimization

Resulting from a vHTS based on a pharmacophore alignment on known β3-adrenoceptor ligands, an aryloxypropanolamine scaffold comprising a thienopyrimidine moiety was further optimized as a human β3-AR agonist, yielding a lead compound with an excellent cellular activity of EC50 = 20 pM, selectivity over hβ1- and hβ2-adrenoceptors and a promising safety profile.