2940-56-9

Basic information

• Product Name: Benzene, 1-(1-bromopropyl)-4-chloro-
• CAS NO: 2940-56-9
• Molecular Formula: C9H10BrCl
• Molecular Weight: 233.535
• Mol File: 2940-56-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(1-bromopropyl)-4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(1-bromopropyl)-4-chloro-(2940-56-9)
• EPA Substance Registry System: Benzene, 1-(1-bromopropyl)-4-chloro-(2940-56-9)

Safety Data

• Hazardous Substances Data: 2940-56-9(Hazardous Substances Data)

Upstream product

• 1798-84-1 1-chloro-4-cyclopropylbenzene 
• 6285-05-8 4'-chloropropiophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 925-90-6 ethylmagnesium bromide 
• 13856-85-4 1-(4-chlorophenyl)-1-propanol 

Downstream Products

• 82756-60-3 1-(4-Chlorphenyl)-propylmalonsaeure 
• 57960-08-4 β-(4-Chlorphenyl)valeriansaeure 
• 111654-22-9 3-phenoxybenzyl 3-ethyl-3-p-chlorophenylpropionate 
• 111654-19-4 ethyl 3-ethyl-3-p-chlorophenyl-propionate 
• 102733-43-7 diethyl 2-(1-(4-chlorophenyl)propyl)malonate 

Relevant articles and documents

Copper-Catalyzed Enantioconvergent Cross-Coupling of Racemic Alkyl Bromides with Azole C(sp2)?H Bonds

The development of enantioconvergent cross-coupling of racemic alkyl halides directly with heteroarene C(sp2)?H bonds has been impeded by the use of a base at elevated temperature that leads to racemization. We herein report a copper(I)/cinchona-alkaloid-derived N,N,P-ligand catalytic system that enables oxidative addition with racemic alkyl bromides under mild conditions. Thus, coupling with azole C(sp2)?H bonds has been achieved in high enantioselectivity, affording a number of potentially useful α-chiral alkylated azoles, such as 1,3,4-oxadiazoles, oxazoles, and benzo[d]oxazoles as well as 1,3,4-triazoles, for drug discovery. Mechanistic experiments indicated facile deprotonation of an azole C(sp2)?H bond and the involvement of alkyl radical species under the reaction conditions.

Glucose transport-enhancing and hypoglycemic activity of 2-methyl-2- phenoxy-3-phenylpropanoic acids

A series of 2-phenoxy-3-phenylpropanoic acids has been prepared which contains many potent hypoglycemic agents as demonstrated by assessing glucose lowering in ob/ob mice. Some compounds (32, 33, 59) normalize plasma glucose in this diabetic model at doses of approximately 1 mg/kg. The mechanism of action of these drugs may involve enhanced glucose transport, especially in fat cells, but the compounds do not stimulate GLUT4 translocation and do not increase the levels of GLUT1 or GLUT4 in vivo. Thus, these compounds may enhance the intrinsic activity of the glucose transporter GLUT1 or GLUT4. Some compounds also modestly decrease hepatocyte gluconeogenesis in vitro, but this is not likely to be a major contributor to the hypoglycemic effect observed in vivo. Likewise, a modest decrease in food consumption observed with some of these compounds was shown by a pair-feeding experiment not to be the primary cause of the hypoglycemia observed.

Synthesis and fibrinolytic activity of β arylaliphatic acids. Quantitative relationships between structure and biological activity

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