294182-27-7

Basic information

• Product Name: 2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]pyridine
• Synonyms: 2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]pyridine
• CAS NO: 294182-27-7
• Molecular Weight: 283.225
• Mol File: 294182-27-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]pyridine(294182-27-7)
• EPA Substance Registry System: 2-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]pyridine(294182-27-7)

Safety Data

• Hazardous Substances Data: 294182-27-7(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 294182-05-1 2,2-difluoro-1-(2,4-difluorophenyl)2-(2-pyridyl)ethanone 
• 267876-28-8 ethyl 2,2-difluoro-2-(pyridin-2-yl)acetate 
• 109-04-6 2-bromo-pyridine 
• 1774-47-6 trimethylsulfoxonium iodide 

Downstream Products

• 1416732-20-1 2-(2,4-difluorophenyl)-1,1-difluoro-1-(pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol 
• 1416733-54-4 C₁₇H₁₁ClF₄N₂OS 
• 1416733-13-5 C₁₇H₁₁F₄N₃O 
• 1416733-53-3 2-(2,4-difluorophenyl)-1,1-difluoro-1-(pyridin-2-yl)-3-(thiazol-5-yl)propan-2-ol 
• 1416733-14-6 C₁₇H₁₅F₄N₅O 
• 1416733-12-4 2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-pyrazol-4-yl)-1-(pyridin-2-yl)propan-2-ol 

Relevant articles and documents

Design and optimization of highly-selective fungal CYP51 inhibitors

While the orally-active azoles such as voriconazole and itraconazole are effective antifungal agents, they potently inhibit a broad range of off-target human cytochrome P450 enzymes (CYPs) leading to various safety issues (e.g., drug-drug interactions, li

New antifungal 1,2,4-triazoles with difluoro(heteroaryl)methyl moiety

New 1,2,4-triazoles (1) having a difluoro(heteroaryl)methyl moiety were designed and synthesized via 1-aryl-2,2-difluoro-2- (heteroaryl)ethanones (2), which were prepared by two routes starting from the reaction of ethyl 2,2- difluoro(heteroaryl)acetate with phenyllithiums (Route A) and from the reaction of chlorodifluoro(heteroaryl)methane with benzaldehydes (Route B). The compounds 1 except for 1g show antifungal activities against yeasts and filamentous fungi in vitro, especially (+)-If have equal or superior activities compared to those of itraconazole.