29425-06-7Relevant articles and documents
Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus
Su, Jung-Chen,Huang, Yu-Ting,Chen, Chang-Shi,Chiu, Hao-Chieh,Shiau, Chung-Wai
, (2018/01/03)
Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.
Novel, malonyl-derived edta analogues
Hagemann, Justin P.,Kaye, Perry T.
, p. 2539 - 2546 (2007/10/03)
Reaction of malonyl dichloride and benzylmalonyl dichloride with iminodiacetate esters has provided access to several, novel EDTA analogues.
Mesoionic Six-Membered Heterocycles, V. Reactions of 6-Oxo-6H-1,3-oxazin-3-ium-4-olates with o-Quinones and Heterocumulenes
Friedrichsen, Willy,Kujath, Eckard,Liebezeit, Gerd
, p. 222 - 233 (2007/10/02)
Mesoionic 6-oxo-6H-1,3-oxazine-3-ium-4-olates (1, 7) react with o-quinones (2, 4) to give compounds 3, 5, which may result from a primary cycloaddition and subsequent loss of carbon dioxide.Phenyl isocyanate and phenylisothiocyanate react with 1h and