29457-07-6

Basic information

• Product Name: TICARCILLIN DISODIUM SALT
• Synonyms: TIMENTIN;TICAR;TICARCILLIN DISODIUM;(2S,5R,6R)-6-[[(2R)-CARBOXY-3-THIENYLACETYL]AMINO]-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID DISODIUM SALT;(2S,5S,6R)-6-[[(2R)-CARBOXY-3-THIENYLACETYL]AMINO]-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3,2,0]HEPT;disodium [2S-[2alpha,5alpha,6beta(S*)]]-6-(carboxylato-3-thienylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;3-Thiophenemalonamic acid, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-, disodium salt, D-(-)- (8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(carboxy-3-thienylacetyl)amino]-3,3-dimethyl-7-oxo-, disodium salt, [2S-[2a,5a,6b(S*)]]-
• CAS NO: 29457-07-6
• Molecular Formula: C₁₅H₁₄N₂O₆S₂*2Na
• Molecular Weight: 428.39
• EINECS: 249-642-5
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;antibiotic;Inhibitors
• Mol File: 29457-07-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 768.3oC at 760 mmHg
• Flash Point: 418.4oC
• Appearance: White Solid
• Vapor Pressure: 7.97E-25mmHg at 25°C
• CAS DataBase Reference: TICARCILLIN DISODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: TICARCILLIN DISODIUM SALT(29457-07-6)
• EPA Substance Registry System: TICARCILLIN DISODIUM SALT(29457-07-6)

Safety Data

• Hazardous Substances Data: 29457-07-6(Hazardous Substances Data)

Usage

Description

Ticarcillin Disodium Salt, a carboxypenicillin antibiotic, belongs to the beta-lactam class of antibiotics. It is a white solid substance known for its effectiveness in treating infections caused by gram-negative bacteria, particularly Pseudomonas aeruginosa.

Uses

Used in Pharmaceutical Industry:
Ticarcillin Disodium Salt is used as an injectable antibiotic for the treatment of infections caused by gram-negative bacteria, such as Pseudomonas aeruginosa. Its application is crucial in combating bacterial infections that are resistant to other types of antibiotics, making it a valuable asset in the fight against antibiotic-resistant strains.
Additionally, Ticarcillin Disodium Salt may be used in combination with other antibiotics, such as clavulanic acid, to enhance its effectiveness against a broader range of bacterial infections. This combination therapy can help in reducing the development of antibiotic resistance and improving patient outcomes.

InChI:InChI=1/C15H16N2O6S2.2Na/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;;/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);;/q;2*+1/p-2/t7-,8-,9+,12-;;/m1../s1

Upstream product

• 21080-92-2 2-(thiophen-3-yl)malonic acid 
• 551-16-6 6-Aminopenicillanic Acid 

Downstream Products

• 85339-60-2 benzyl 6β-penicillanate 

Relevant articles and documents

Preparation method for ticarcillin sodium

The invention discloses a preparation method for ticarcillin sodium. The preparation method comprises the steps that 3-thienylmalonic acid and pivaloyl chloride react in the presence of triethylamine to obtain mixed anhydride; 6-APA and N,O-bis(trimethylsilyl) acetamide react to obtain silylanized 6-APA; then the mixed anhydride reacts with the 6-APA to obtain ticarcillin acid; the ticarcillin acid further reacts with sodium iso-octoate to obtain ticarcillin sodium. The method has the advantages of being mild in reaction condition, simple in operation, simple in post-treatment, friendly to environment, high in product yield and purity and the like.