29458-39-7

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 6-methoxy-3-methyl-
• CAS NO: 29458-39-7
• Molecular Formula: C6H8N2O3
• Molecular Weight: 156.141
• Mol File: 29458-39-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 6-methoxy-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 6-methoxy-3-methyl-(29458-39-7)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 6-methoxy-3-methyl-(29458-39-7)

Safety Data

• Hazardous Substances Data: 29458-39-7(Hazardous Substances Data)

Usage

General Description

2,4(1H,3H)-Pyrimidinedione, 6-methoxy-3-methyl- is a chemical compound with the molecular formula C6H6N2O3. It is a derivative of pyrimidine and is characterized by the presence of a methoxy group at the 6-position and a methyl group at the 3-position of the pyrimidine ring. 2,4(1H,3H)-Pyrimidinedione, 6-methoxy-3-methyl- has potential applications in the pharmaceutical industry, particularly in the development of pharmaceutical drugs for various medical conditions. Its specific properties and potential uses make it an interesting target for further research and development.

Upstream product

• 67-56-1 methanol 
• 2565-47-1 1-methyl-2,4,6-pyrimidinetrione 
• 186581-53-3 diazomethane 

Relevant articles and documents

SOLVATION EFFECTS IN THE METHYLATION OF BARBITURIC ACID AND ITS DERIVATIVES BY DIAZOMETHANE

Methylation of barbituric acid and its N-methylderivatives by diazomethane in ethers and methanol occurs only at the oxygen atom of the β-dicarbonyl fragment.The resulting 6-methoxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidine and its derivatives are methylated at both the oxygen and nitrogen atoms; relative to ethers, methanol facilitates a greater degree of methylation at the nitrogen atom.

REACTION OF BARBITURIC ACID AND ITS METHYL DERIVATIVES WITH DIAZOMETHAN IN ETHERS

A full scheme for the methylation of barbituric acid with diazomethane in diethyl ether, glyme, and THF was formulated.For barbituric acid and its N-methyl derivatives the reaction takes place at the oxygen atoms of the β-dicarbonyl fragment.The 6-methoxyuracil and its derivatives which are formed here are subsequently methylated at the nitrogen and oxygen atoms.The reaction takes place in accordance with the structures of the monoanions of the compounds being methylated.