2946-89-6Relevant articles and documents
Structure and synthesis of 3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine
Ozerova,Efimova,Novikova,Gurzhii,Berestovitskaya
, p. 1623 - 1628 (2015)
A new approach to the synthesis of 3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine was developed based on condensing 1-amino-2-nitroguanidine with pentane-2,4-dione under alkaline catalysis. The known method of its preparation in the presence of acetic acid was improved. The structure of 3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine was characterized by NMR, IR spectroscopy and X-ray diffraction analysis.
Optimisation of the synthesis of guanidines from amines via nitroguanidines using 3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine
Castillo-Melendez, Joel A.,Golding, Bernard T.
, p. 1655 - 1663 (2007/10/03)
The synthesis of the useful reagent for the preparation of guanidines, 3,5-dimethyl-N-nitro-1-pyrazole-1-carboxamidine (DMNPC), has been optimised. A detailed protocol for using this reagent for the preparation in pure form of a range of guanidines via nitroguanidines is described. A comparison has been made regarding efficiency between DMNPC and the guanidinylating reagents N,N′-bis-Boc-1-pyrazole-1-carboxamidine (2) and N,N′-bis-Boc- N′-triflylguanidine (3).
Enzyme Inhibiting substance
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, (2008/06/13)
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