29462-24-6Relevant articles and documents
Synthesis of 2-amino-3-heteroaroylthiophenes and evaluation of their activity as potential allosteric enhancers at the human A1 receptor
Baraldi, Pier Giovanni,Pavani, Maria Giovanna,Shryock, John C.,Moorman, Allan R.,Iannotta, Valeria,Borea, Pier Andrea,Romagnoli, Romeo
, p. 855 - 865 (2004)
2-Amino-3-benzoylthiophenes are allosteric enhancers of agonist binding to the adenosine A1 receptor. New compounds bearing an heteroaroyl instead of the benzoyl moiety at the 3-position of the thiophene were synthesized. The phenyl ring was re
Allosteric adenosine receptor modulators
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Page column 16, (2008/06/13)
The present invention relates to compounds of formula (IA): the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators for uses including protection against hypoxia and ischemia induced injury and treatment of adenosine-sensitive cardiac arrhythmias.