2950-88-1

Basic information

• Product Name: ethyl 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoate
• CAS NO: 2950-88-1
• Molecular Formula: C₉H₁₁N₃O₆
• Molecular Weight: 257.2001
• Mol File: 2950-88-1.mol
• Article Data: 2

Chemical Properties

• Density: 1.46g/cm³
• Refractive Index: 1.561
• CAS DataBase Reference: ethyl 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoate(2950-88-1)
• EPA Substance Registry System: ethyl 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoate(2950-88-1)

Safety Data

• Hazardous Substances Data: 2950-88-1(Hazardous Substances Data)

Upstream product

• 611-08-5 5-nitrobarbituric acid 
• 140-88-5 ethyl acrylate 
• 539-74-2 Ethyl 3-bromopropionate 

Downstream Products

• 2950-92-7 ethyl 3-[5-amino-2,4-(1H,3H)pyrimidinedione]propanoate 
• 148-08-3 3-(5--3,4-dihydro-2,4-dioxo-1(2H)-pyrimidin)-propionsaeure 

Relevant articles and documents

Facile aza-Michael additions of uracil derivatives to acrylates

24 Aza-Michael adducts were synthesised in moderate to excellent yields by the addition of 5-substituted uracils to acrylates with ethylamine as a catalyst. Many of the adducts were obtained in almost quantitive yield without column chromatography. The procedure provideded an efficient approach to the synthesis of N-1 uracil adducts using acrylates as acceptors. The structures of the compounds were determined by 1H NMR, 13C NMR, mass spectra and X-ray crystallography analyses. The uracil unit is present in DNA and related natural products and has a broad spectrum of biological activity.