295320-25-1 Usage
Description
BENZYL 3-HYDROXYPHENYLACETATE, also known as Benzyl 2-(3-Hydroxyphenyl)acetate, is an organic compound that serves as an intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its benzyl and 3-hydroxyphenylacetate functional groups, which contribute to its chemical properties and reactivity.
Used in Pharmaceutical Industry:
BENZYL 3-HYDROXYPHENYLACETATE is used as an intermediate in the synthesis of Nahlsgen (N497063) for its role as a highly selective and irreversible γ-glutamyl transpeptidase (GGT) inhibitor. This selective inhibition is significant as it does not exhibit inhibitory activity on glutamine amidotransferases, making it a potentially valuable compound in the development of targeted therapies for specific conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 295320-25-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,5,3,2 and 0 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 295320-25:
(8*2)+(7*9)+(6*5)+(5*3)+(4*2)+(3*0)+(2*2)+(1*5)=141
141 % 10 = 1
So 295320-25-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H14O3/c16-14-8-4-7-13(9-14)10-15(17)18-11-12-5-2-1-3-6-12/h1-9,16H,10-11H2
295320-25-1Relevant articles and documents
Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity
Kamiyama, Akane,Nakajima, Mado,Han, Liyou,Wada, Kei,Mizutani, Masaharu,Tabuchi, Yukiko,Kojima-Yuasa, Akiko,Matsui-Yuasa, Isao,Suzuki, Hideyuki,Fukuyama, Keiichi,Watanabe, Bunta,Hiratake, Jun
supporting information, p. 5340 - 5352 (2016/10/24)
γ-Glutamyl transpeptidase (GGT, EC 2.3.2.2) that catalyzes the hydrolysis and transpeptidation of glutathione and its S-conjugates is involved in a number of physiological and pathological processes through glutathione metabolism and is an attractive phar
Substituted compounds derived from N-(benzyl)phenylacetamide, preparation and uses
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Page/Page column 47, (2010/10/20)
This invention relates to poly-substituted derivatives of the N-(benzyl)phenylacetamide type, pharmaceutical compositions comprising same, therapeutic uses thereof, more particularly in the fields of human and animal health. This invention also relates to a process for the preparation of such derivatives.
