2955-37-5

Basic information

• Product Name: 7-Chloro-2-oxo-5-(2-chlorophenyl)-1,4-benzodiazepine-4-oxide
• Synonyms: 7-CHLORO-5-(2-CHLORO-PHENYL)-4-OXY-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE;7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-benzo-1,4-diazepin-2-one 4-oxide;Lorazepam7-Chloro-2-Oxo-5-(2-Chlorohenyl)-1,4-Benzodiazepine-4-Oxide;7-CHLORO-2-OXO-5-(2-CHLOROPHENYL)-1,4-BENZODIAZEPINE-4-OXIDE;7-CHLORO-2-OXO-5-(2-CHOLROPHENYL)1,4-BENZODIAZEPINE-4-OXIDE;7-Chloro-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one 4-oxide;7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-Oxide;DelorazepaM 4-Oxide
• CAS NO: 2955-37-5
• Molecular Formula: C₁₅H₁₀Cl₂N₂O₂
• Molecular Weight: 321.16
• EINECS: 220-974-2
• Mol File: 2955-37-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 476.5oC at 760 mmHg
• Flash Point: 242oC
• Appearance: /
• Density: 1.49 g/cm³
• Vapor Pressure: 6.91E-10mmHg at 25°C
• Refractive Index: 1.678
• CAS DataBase Reference: 7-Chloro-2-oxo-5-(2-chlorophenyl)-1,4-benzodiazepine-4-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-2-oxo-5-(2-chlorophenyl)-1,4-benzodiazepine-4-oxide(2955-37-5)
• EPA Substance Registry System: 7-Chloro-2-oxo-5-(2-chlorophenyl)-1,4-benzodiazepine-4-oxide(2955-37-5)

Safety Data

• Hazardous Substances Data: 2955-37-5(Hazardous Substances Data)

Usage

Description

7-Chloro-2-oxo-5-(2-chlorophenyl)-1,4-benzodiazepine-4-oxide is a chemical compound belonging to the benzodiazepine class. It is characterized by its unique molecular structure, which features a benzene ring fused to a diazepine ring, with a chloro substituent at the 7th position and a 2-chlorophenyl group at the 5th position. 7-Chloro-2-oxo-5-(2-chlorophenyl)-1,4-benzodiazepine-4-oxide is an N-oxide derivative of Delorazepam, which is an intermediate in the synthesis of Lorazepam.

Uses

Used in Pharmaceutical Industry:
7-Chloro-2-oxo-5-(2-chlorophenyl)-1,4-benzodiazepine-4-oxide is used as an intermediate in the synthesis of Lorazepam, a widely prescribed benzodiazepine medication. Lorazepam is utilized for its anxiolytic, anticonvulsant, sedative, and amnestic properties, making it a valuable compound in the development of pharmaceuticals for treating anxiety, seizures, and other related conditions.
Used in Research and Development:
7-Chloro-2-oxo-5-(2-chlorophenyl)-1,4-benzodiazepine-4-oxide serves as a valuable research tool for scientists and researchers working on the development of new benzodiazepine-based drugs. Its unique structure and properties make it an interesting candidate for further investigation and potential modification to enhance its therapeutic effects or reduce side effects associated with benzodiazepines.
Used in Quality Control and Standardization:
7-Chloro-2-oxo-5-(2-chlorophenyl)-1,4-benzodiazepine-4-oxide can be employed as a reference compound in the quality control and standardization of benzodiazepine medications. Its well-defined structure and properties allow for accurate measurement and comparison with other compounds in the class, ensuring the consistency and reliability of pharmaceutical products.

InChI:InChI=1/C15H10Cl2N2O2/c16-9-5-6-13-11(7-9)15(19(21)8-14(20)18-13)10-3-1-2-4-12(10)17/h1-7,21H,8H2

Upstream product

• 2894-67-9 delorazepam 
• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 

Downstream Products

• 89722-85-0 Trifluoro-acetic acid 7-chloro-5-(2-chloro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl ester 
• 846-49-1 lorazepam 
• 60628-58-2 3-Fluoro-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one 
• 60628-61-7 7-chloro-5-(2-chloro-phenyl)-3-fluoro-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 206127-03-9 Re(CO)2(P(C₆H₅)3)2(C₁₅H₉Cl₂N₂O₂) 

Relevant articles and documents

Preparation method of lorazepam intermediate

The invention discloses a preparation method of a lorazepam intermediate. The preparation method comprises the following steps: taking 7-chloro-5-(-2-chlorphenyl)-1, 3-dihydro-2H-1, 4-benzodiazepine-2-ketone as a raw material, carrying out oxidation reaction with hydrogen peroxide in an aprotic polar solvent without an acidic solvent, and after the reaction is finished, carrying out aftertreatmentto obtain the 7-chloro- dioxo-5-(2chlorphenyl) 1, 3-dihydro-2H-1, 4-benzodiazepine. The invention relates to a 4-benzodiazepine-4-oxide. According to the preparation method, expensive raw materials do not need to be used for catalysis in the reaction process, operations such as reaction quenching, solvent extraction and concentration distillation do not need to be carried out in the post-treatment process, operation steps are reduced, the production period is shortened, the production cost is reduced, and the preparation method is suitable for industrial production.