2960-93-2

Basic information

• Product Name: (R)-(+)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL
• Synonyms: NSC 244962;NSC 37210;2,2'-Dimethoxy-1,1'-binaphthalene 97%;(S)-(-)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL;(S)-(+)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL;(S)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL;(R)-(+)-1,1'-BI-2-NAPHTHOL DIMETHYL ETHER;(R)-(+)-2,2'-DIMETHOXY-1,1'-BI-NAPHTHOL
• CAS NO: 2960-93-2
• Molecular Formula: C22H18O2
• Molecular Weight: 314.38
• Mol File: 2960-93-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 227-231 °C(lit.)
• Boiling Point: 414.05°C (rough estimate)
• Flash Point: 152.5 °C
• Appearance: White to beige/Crystalline Powder
• Density: 1.160
• Refractive Index: 1.5100 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: (R)-(+)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL(2960-93-2)
• EPA Substance Registry System: (R)-(+)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL(2960-93-2)

Safety Data

• Hazard Codes: Xi,N
• Statements: 41-50/53-37/38
• Safety Statements: 26-36/39-60-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• HazardClass: 9
• Hazardous Substances Data: 2960-93-2(Hazardous Substances Data)

Usage

Description

(R)-(+)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL is a chiral compound characterized by its white to beige crystalline powder form. It is an organic chemical synthesis intermediate, playing a crucial role in the production of various pharmaceuticals and specialty chemicals.

Uses

Used in Pharmaceutical Industry:
(R)-(+)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL is used as a key intermediate in the synthesis of chiral pharmaceuticals. Its unique stereochemistry allows for the creation of enantiomerically pure compounds, which are essential for the development of drugs with improved efficacy and reduced side effects.
Used in Specialty Chemicals:
(R)-(+)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL is also utilized as a precursor in the synthesis of specialty chemicals, such as chiral ligands and catalysts. These applications are vital in various chemical processes, including asymmetric catalysis and enantioselective synthesis, where the control of stereochemistry is crucial for achieving desired product outcomes.

Upstream product

• 602-09-5 (-)-2,2'-dihydroxy-1,1'-binaphthyl 
• 77-78-1 dimethyl sulfate 
• 18531-94-7 (+)-2,2'-dihydroxy-1,1'-binaphthyl 

Relevant articles and documents

Spontaneous Resolution of 2,2'-Dimethoxy-1,1'-binaphthalene

The dimethyl ether of 1,1'-bi-2-naphthol crystallizes as a conglomerate and can be resolved without chiral auxiliaries by entrainment.The direct crystallization of a supersaturated solution of the title compound partially enriched by one enantiomer (ee ca. 2percent) is conducted in anisole at 40 deg C and gives, after one crystallization, a compound with ee >98percent.Demethylation under nonracemizing conditions gives the enantiomeric 1,1'-bi-2-naphthol.