296272-05-4

Basic information

• Product Name: 2-(4-methoxyphenyl)-2,3-dihydrobenzo[e][1,3]oxazin-4-one
• Synonyms: 2-(4-methoxyphenyl)-2,3-dihydrobenzo[e][1,3]oxazin-4-one
• CAS NO: 296272-05-4
• Molecular Weight: 255.273
• Mol File: 296272-05-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-2,3-dihydrobenzo[e][1,3]oxazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-2,3-dihydrobenzo[e][1,3]oxazin-4-one(296272-05-4)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-2,3-dihydrobenzo[e][1,3]oxazin-4-one(296272-05-4)

Safety Data

• Hazardous Substances Data: 296272-05-4(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 65-45-2 salicylamide 
• 7647-01-0 hydrogenchloride 
• 90-02-8 salicylaldehyde 

Downstream Products

• 123-11-5 4-methoxy-benzaldehyde 
• 65-45-2 salicylamide 

Relevant articles and documents

Synthesis and anticonvulsant activity evaluation of 2-Phenyl-2H-benzo[e][1, 3]oxazin-4(3H)-ones

A series of new 2-phenyl-2H-benzo[e][1,3]oxazin-4(3H)-one derivatives (1a-1t) were designed based on the known anticonvulsant activity of quinolinone derivatives. All target compounds 1a-1t, characterized by IR, 1H NMR and MS, have been evaluated for their anticonvulsant activity against MES-induced seizures. The pharmacological results showed that all the compounds displayed some degree of anticonvulsant activity. Among them, 2-phenyl-2,3-dihydrobenzo[e][1,3]oxazin-4-one (1a) and 2-(2-fluorophenyl)-2,3- dihydrobenzo-[e][1,3]oxazin-4- one (1b) were considerd more promising because of their lower ED50 (34.1 and 28.4 mg/kg) and higher protective index (11.1 and 8.0).