29638-33-3

Basic information

• Product Name: 2-(5-MERCAPTO-1,3,4-OXADIAZOL-2-YL)PHENOL
• Synonyms: OTAVA-BB BB7110952592;AKOS BBS-00002155;AKOS TOT-0403;2-(5-MERCAPTO-1,3,4-OXADIAZOL-2-YL)PHENOL;AURORA 23285;ART-CHEM-BB B023276
• CAS NO: 29638-33-3
• Molecular Formula: C₈H₆N₂O₂S
• Molecular Weight: 194.21
• Mol File: 29638-33-3.mol
• Article Data: 29

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(5-MERCAPTO-1,3,4-OXADIAZOL-2-YL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-MERCAPTO-1,3,4-OXADIAZOL-2-YL)PHENOL(29638-33-3)
• EPA Substance Registry System: 2-(5-MERCAPTO-1,3,4-OXADIAZOL-2-YL)PHENOL(29638-33-3)

Safety Data

• Hazardous Substances Data: 29638-33-3(Hazardous Substances Data)

Usage

Chemical structure

Contains a phenol ring, an oxadiazole ring, and a thiol group

Usage

Building block in the synthesis of pharmaceuticals, agrochemicals, and materials

Properties

Antioxidant and antibacterial

Potential applications

Medicine, materials science, and drug development

Importance

Valuable for research and development of new drugs with various biological activities

Upstream product

• 75-15-0 carbon disulfide 
• 936-02-7 2-Hydroxybenzoylhydrazine 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 69-72-7 salicylic acid 
• 119-36-8 methyl salicylate 
• 70203-02-0 N'-(2-phenyl-2-ethylidene)-2-hydroxybenzohydrazide 
• 137-26-8 Thiram 

Downstream Products

• 54543-83-8 5-(2-hydroxyphenyl)-3-[(3-nitroanilino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 54543-77-0 3-[(2-ethoxyanilino)methyl]-5-(2-hydroxyphenyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 54543-74-7 5-(2-hydroxy-phenyl)-3-(2-methyl-anilinomethyl)-3H-[1,3,4]oxadiazole-2-thione 
• 54543-79-2 3-[(4-bromoanilino)methyl]-5-(2-hydroxyphenyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 1260218-12-9 2-(5-((2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-1,3,4-oxadiazol-2-yl)phenol 
• 336173-67-2 N-phenyl-5-(2-phenolyl-1,3,4-oxadiazolyl)thioacetamide 
• 22706-15-6 4-amino-2,4-dihydro-5-(2-hydroxyphenyl)-3H-1,2,4-triazole-3-thione 
• 322479-26-5 3-(2-hydroxy-phenyl)-5-mercapto-[1,2,4]triazol-4-ol 
• 158361-94-5 2-benzylmercapto-5-(2-hydroxyphenyl)-1,3,4-oxadiazole 
• 54543-78-1 3-(4-ethoxy-anilinomethyl)-5-(2-hydroxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione 
• 54543-73-6 3-(anilinomethyl)-5-(2-hydroxyphenyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 54543-84-9 5-(2-hydroxyphenyl)-3-[(4-nitroanilino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 54587-75-6 3-(4-dimethylamino-anilinomethyl)-5-(2-hydroxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione 
• 54543-86-1 4-{[5-(2-hydroxy-phenyl)-2-thioxo-[1,3,4]oxadiazol-3-ylmethyl]-amino}-benzoic acid 

Relevant articles and documents

A new colorimetric chemosensor based on 1,3,4-oxadiazole derivative for the high selectivity and sensitivity of Fe3+ ion detection

This paper reports the development of new iron chemosensor, 2-(5-sulfanyl-1,3,4-oxadiazol-2-yl) phenol (HL). The structural properties of HL were confirmed by FTIR, 1H NMR, 13C NMR and ESI–MS techniques. The sensor was applied for detection of various metal ions in DMF/H2O (1:9 v/v) medium. The results revealed an instant color change of Fe3+ solution from yellow to black. However, white and light brown precipitates were observed in the case of Pb2+, Hg2+ and Cu2+, respectively, whereas no optical response for the other cations were detected. Beside its high selectivity for Fe3+, no interference from other co-existed ions was seen. Moreover, the detection limit (LOD) of 3 μM, which is less than the acceptable value of the Fe3+ from WHO in environment, was observed. The interaction between Fe3+ ions and HL sensor using Job's plot analysis was found to be a 1:1 binding stoichiometry with a binding constant of 1.8 × 103 M?1 as calculated using Benesi–Hilderbrand equation. The advantage of HL in propping of Fe3+in real environmental samples were also tested which revealed its practical applicability as an effective chemosensor.

Pleuromutilin derivative with 1, 3, 4-oxadiazole side chain and preparation and application thereof

The invention belongs to the field of medicinal chemistry, and particularly relates to a pleuromutilin derivative with a 1, 3, 4-oxadiazole side chain and preparation and application thereof The pleuromutilin derivative with the 1, 3, 4-oxadiazole side chain is a compound shown in a formula 2 or a pharmaceutically acceptable salt thereof, and a solvent compound, an enantiomer, a diastereoisomer and a tautomer of the compound shown in the formula 2 or the pharmaceutically acceptable salt thereof or a mixture of the solvent compound, the enantiomer, the diastereoisomer and the tautomer in any proportion, including a racemic mixture. The pleuromutilin derivative has good antibacterial activity, is especially suitable for being used as a novel antibacterial agent for systemic system infection of animals or human beings, and has good water solubility.

1, 3, 4-oxadiazole-2 (3H)-thioketone-norfloxacin heterozygote and preparation method and application thereof

The invention discloses a 1, 3, 4-oxadiazole-2 (3H)-thioketone-norfloxacin heterozygote and a preparation method and application thereof, and the structural formula of the 1, 3, 4-oxadiazole-2 (3H)-thioketone-norfloxacin heterozygote is shown as a formula