296776-79-9

Basic information

• Product Name: (S)-3-(o-tolyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide
• Synonyms: (S)-3-(o-tolyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide
• CAS NO: 296776-79-9
• Molecular Weight: 259.329
• Mol File: 296776-79-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (S)-3-(o-tolyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(o-tolyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide(296776-79-9)
• EPA Substance Registry System: (S)-3-(o-tolyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide(296776-79-9)

Safety Data

• Hazardous Substances Data: 296776-79-9(Hazardous Substances Data)

Upstream product

• 5669-05-6 1,2-benzoisothiazole 1,1-dioxide 
• 16419-60-6 2-Methylphenylboronic acid 
• 932-31-0 ortho-tolylmagnesium bromide 
• 81-07-2 saccharin 
• 55379-01-6 3-(2-methylphenyl)-1,2-benzisothiazole 1,1-dioxide 
• 529-20-4 2-methylphenyl aldehyde 

Relevant articles and documents

Ni(II)/tBu-SMI-PHOX catalyzed enantioselective addition of arylboronic acids to cyclic N-sulfonyl aldimines

An efficient Ni(ClO4)2·6H2O/SMI-PHOX catalyzed enantioselective addition of arylboronic acids to cyclic N-sulfonyl aldimines is envisioned to afford excellent enantioselectivities (up to 99% ee) in high yields (up to 98%). This protocol offers new opportunities for the synthesis of chiral benzosultams containing a stereogenic tertiary carbon center. The highlights of this method include mild reaction conditions, the use of cheap metal catalyst and a wide substrate scope.

Method for synthesizing chiral sulfanilamides through asymmetric intramolecular reduction and amination under catalysis of palladium

The invention provides a method for synthesizing chiral sulfanilamides through asymmetric intramolecular reduction and amination under catalysis of palladium. A catalysis system used in the method is a chiral diphosphine complexe. Corresponding chiral sulfanilamides are obtained through reduction and amination of a simple and easily available ketoamine substrate, and enantiomeric excess can reach 99%. The method is simple to operate, practical and feasible; raw materials are simple and easily available; the catalyst is commercially available; and reaction conditions are mild. Moreover, high enantioselectivity, good yield and environment friendliness are realized in synthesis of chiral sulfanilamides through asymmetric reduction and amination.

An N-heterocyclic carbene iridium catalyst with metal-centered chirality for enantioselective transfer hydrogenation of imines

A cyclometalating N-heterocyclic carbene iridium complex featuring metal-centered chirality was designed and used for the asymmetric transfer hydrogenation (ATH) of imines. Four strongly σ-donating carbon-based substituents (2 carbenes and 2 phenyl moieti