296776-84-6

Basic information

• Product Name: Pyridine, 2-(4-methoxyphenyl)-5-(trifluoromethyl)-
• CAS NO: 296776-84-6
• Molecular Formula: C13H10F3NO
• Molecular Weight: 253.224
• Mol File: 296776-84-6.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-(4-methoxyphenyl)-5-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(4-methoxyphenyl)-5-(trifluoromethyl)-(296776-84-6)
• EPA Substance Registry System: Pyridine, 2-(4-methoxyphenyl)-5-(trifluoromethyl)-(296776-84-6)

Safety Data

• Hazardous Substances Data: 296776-84-6(Hazardous Substances Data)

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 174485-72-4 5-trifluoromethyl-pyridin-2-ylsulfonylchloride 
• 5720-07-0 4-methoxyphenylboronic acid 
• 50488-42-1 2-bromo-5-(trifluoromethyl)pyridine 
• 76041-72-0 2-mercapto-5-trifluoromethylpyridine 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 80194-69-0 5-(trifluoromethyl)picolinic acid 
• 88345-93-1 5-bromo-2-(4-methyloxyphenyl)pyridine 
• 623-12-1 4-chloromethoxybenzene 
• 1227700-47-1 6-methyl-2-[5-trifluoromethyl]-2-pyridyl-1,3,6,2-dioxazaborocane-4,8-dione 
• 97302-05-1 di-4-methoxyphenylzinc 

Relevant articles and documents

Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions

Heteroaromatic sulfinates are effective nucleophilic reagents in Pd0-catalyzed cross-coupling reactions with aryl halides. However, metal sulfinate salts can be challenging to purify, solubilize in reaction media, and are not tolerant to multi-step transformations. Here we introduce base-activated, latent sulfinate reagents: β-nitrile and β-ester sulfones. We show that under the cross-coupling conditions, these species generate the sulfinate salt in situ, which then undergo efficient palladium-catalyzed desulfinative cross-coupling with (hetero)aryl bromides to deliver a broad range of biaryls. These latent sulfinate reagents have proven to be stable through multi-step substrate elaboration, and amenable to scale-up.

Generation of Organozinc Reagents from Arylsulfonium Salts Using a Nickel Catalyst and Zinc Dust

Readily available aryldimethylsulfonium triflates react with zinc powder under nickel catalysis via the selective cleavage of the sp2-hybridized carbon-sulfur bond to produce salt-free arylzinc triflates under mild conditions. This zincation displays superb chemoselectivity and thus represents a protocol that is complementary or orthogonal to existing methods. The generated arylzinc reagents show both high reactivity and chemoselectivity in palladium-catalyzed and copper-mediated cross-coupling reactions.

Transition-Metal-Free Desulfinative Cross-Coupling of Heteroaryl Sulfinates with Grignard Reagents

A mild cross-coupling reaction of heteroaryl sulfinates with Grignard reagents has been developed under transition-metal-free conditions. This study provides an example of the SO22- as a leaving group in an aromatic system and an effective methodology for the construction of C-C bond.