29706-85-2

Basic information

• Product Name: 3'-AZIDO-2',3'-DIDEOXY-THYMIDINE-5'-MONOPHOSPHATE, SODIUM SALT
• Synonyms: 3’-azido-3’-deoxythymidine5’phosphate;3'-AZIDO-3'-DEOXYTHYMIDINE 5'-MONOPHOSPHATE, SODIUM SALT;3'-AZIDO-2',3'-DIDEOXY-THYMIDINE-5'-MONOPHOSPHATE, SODIUM SALT;AZT MONOPHOSPHATE, SODIUM SALT;AZTMP SODIUM SALT;3'-azido-3'-deoxythymidine 5'-*monophosphate sodi;3'-AZIDO-3'-DEOXYTHYMIDINE 5'-*MONOPHOSPHATE SODIUM;Zidovudinemonophosphate
• CAS NO: 29706-85-2
• Molecular Formula: C₁₀H₁₄N₅O₇P
• Molecular Weight: 369.2
• Product Categories: Metabolites;Bases & Related Reagents;Metabolites & Impurities;Nucleotides
• Mol File: 29706-85-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 154-160°C (dec.)
• Appearance: Pale yellow solid
• Storage Temp.: −20°C
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
• CAS DataBase Reference: 3'-AZIDO-2',3'-DIDEOXY-THYMIDINE-5'-MONOPHOSPHATE, SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-AZIDO-2',3'-DIDEOXY-THYMIDINE-5'-MONOPHOSPHATE, SODIUM SALT(29706-85-2)
• EPA Substance Registry System: 3'-AZIDO-2',3'-DIDEOXY-THYMIDINE-5'-MONOPHOSPHATE, SODIUM SALT(29706-85-2)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36
• Hazardous Substances Data: 29706-85-2(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Upstream product

• 312750-67-7 O-(N^α-tert-butoxycarbonyl-L-tert-butoxytyrosinyl) O-(S-pivaloyl-2-thioethyl) 3'-azido-2',3'-deoxythymidin-5'-yl phosphate 
• 195885-78-0 1-[(2R,4S,5S)-4-Azido-5-(6-nitro-2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 195885-79-1 1-[(2R,4S,5S)-4-Azido-5-(6-chloro-2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 195885-82-6 1-[(2R,4S,5S)-4-Azido-5-(8-methoxy-2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 195885-81-5 1-[(2R,4S,5S)-4-Azido-5-(6-methoxy-2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 195885-85-9 1-[(2R,4S,5S)-4-Azido-5-(6,8-dimethyl-2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 195885-83-7 1-[(2R,4S,5S)-4-Azido-5-(6-methyl-2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 195885-84-8 cyclo-3-methylsaligenyl 3'-azido-2',3'-dideoxythymidine monophosphate 
• 195885-80-4 1-[(2R,4S,5S)-4-Azido-5-(2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 171284-24-5 4-butanoyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate 

Downstream Products

• 106060-89-3 3'-azido-3'-deoxythymidine-5'-diphosphate 
• 329237-23-2 O-cyclohexyl-O'-(3'-azido-3'-deoxythymidin-5'-yl) phosphonate 
• 244642-03-3 O-benzyl-O'-(3'-azido-3'-deoxythymidin-5'-yl) phosphonate 
• 124930-59-2 3'-azido-3'-deoxythymidin-5'-yl H-phosphonate monoester 
• 30516-87-1 3'-azido-2',3'-deoxythymidine 

Relevant articles and documents

Design of new mononucleotide prodrugs: Aryl (SATE) phosphotriester derivatives

Synthesis, biological activities and decomposition kinetics of novel phosphotriester derivatives of 3′-azido-2′,3′-dideoxythymidine (AZT) bearing a S-tButyl-2-thioethyl (tBuSATE) group and L-tyrosinyl residues are reported. All the derivatives appeared to

As

The synthesis of cycloSal-AZTMPs 3a-h as new pro-nucleotides of AZTMP 2 is described. Phosphotriesters 3 selectively release AZTMP 2 by a controlled, chemically induced tandem reaction. Cyc/oSal-AZTMPs 3 exhibited high biological activity in HIVl/HIV-2 infected CEM/O cells but lost their activity nearly completely in CEM/TK cells. Copyright