2973-26-4

Basic information

• Product Name: 2-phenyl-4-quinolinecarbonitrile
• Synonyms: 2-phenyl-4-quinolinecarbonitrile
• CAS NO: 2973-26-4
• Molecular Weight: 230.269
• Mol File: 2973-26-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-phenyl-4-quinolinecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-4-quinolinecarbonitrile(2973-26-4)
• EPA Substance Registry System: 2-phenyl-4-quinolinecarbonitrile(2973-26-4)

Safety Data

• Hazardous Substances Data: 2973-26-4(Hazardous Substances Data)

Upstream product

• 612-96-4 2-Phenylquinoline 
• 506-68-3 bromocyane 
• 74-90-8 hydrogen cyanide 
• 71-43-2 benzene 
• 5807-02-3 4-morpholinoacetonitrile 
• 21236-85-1 quinoline-4-carbonitrile 1-oxide 
• 98-80-6 phenylboronic acid 
• 132-60-5 cinchophen 
• 107-13-1 acrylonitrile 
• 1750-36-3 (E)-N-benzylidenebenzenamine 
• 29197-45-3 2-phenyl quinoline-4-carboxamide 

Downstream Products

• 74831-35-9 C₂₂H₁₅N₂O 
• 74831-37-1 1-Hydroxy-2,2-diphenyl-1,2-dihydro-quinoline-4-carbonitrile 
• 78812-01-8 4-Guanidinomethyl-2-phenylquinoline hydrochloride 
• 29312-45-6 1-oxy-2-phenyl-quinoline-4-carbonitrile 
• 25888-54-4 2-phenyl-quinoline-4-carbothioic acid amide 
• 114493-14-0 2-phenyl-quinoline-4-carbonimidic acid-(N-methyl-anilide) 
• 114509-69-2 2-phenyl-quinoline-4-carbonimidic acid-[2]naphthylamide 
• 110195-24-9 2-phenyl-quinoline-4-carbonimidic acid anilide 
• 110330-72-8 2-phenyl-quinoline-4-carbonimidic acid diethylamide 
• 114493-15-1 2-phenyl-quinoline-4-carbonimidic acid p-toluidide 
• 106883-96-9 2-phenyl-quinoline-4-carbonimidic acid amide 
• 7505-73-9 1-(2-phenylquinolin-4-yl)ethan-1-one 

Relevant articles and documents

Direct arylation for the synthesis of 2-arylquinolines from N-methoxyquinoline-1-ium tetrafluoroborate salts and arylboronic acids

A rapid and direct arylation reaction of N-methoxyquinoline-1-ium tetrafluoroborate derivatives and arylboronic acids with high regioselectivety at room temperature was discovered. The reaction shows exceptional functional group tolerance and broad substrate scope regarding both the quinoline derivatives and the arylboronic acids.

QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS

The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and nonneoplastic diseases.

Quinoline Nitroxide Radicals. Ipso-Attack in the Reaction between 2-Methoxy and 2-Cyanoquinoline N-oxide, and Phenylmagnesium Bromide

2-Methoxy and 2-cyanoquinoline N-oxide, when treated with phenylmagnesium bromide, undergo a nucleophilic ipso-attack at C-2, yielding, by elimination of methoxymagnesium bromide or cyanomagnesium bromide, the corresponding 2-phenylquinoline N-oxides, which react with the excess of Grignard reagents forming 2,2-diphenylquinoline 1-oxyls.Even when the methoxy and cyano groups are in position 4, the attack by the Grignard reagent takes place at C-2 giving 2-phenylquinolines and 2-phenylquinoline N-oxides by elimination by hydroxymagnesium bromide and bromomagnesium hydride, respectively; the formation of 2,2-diphenylquinoline 1-oxyls in these reactions is discussed.