29734-68-7 Usage
Description
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE is a complex organic compound with a unique molecular structure. It is characterized by its octahydro-1H,12H-benzo[i]pyrano[3,4-g]indolizin-12-one core, which is further modified by a 2-methoxy group and a hydrobromide ion. (2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE is likely to have specific properties and applications in various fields due to its intricate molecular architecture.
Uses
Used in Pharmaceutical Industry:
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE is used as a potential therapeutic agent for [application reason]. Its unique molecular structure may allow it to interact with specific biological targets, making it a candidate for the development of new drugs to treat various diseases.
Used in Chemical Research:
In the field of chemical research, (2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE serves as a valuable compound for studying [application reason]. Its synthesis and reactivity can provide insights into the development of new synthetic methods and the understanding of complex molecular interactions.
Used in Material Science:
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE is used as a component in the development of novel materials for [application reason]. Its specific properties, such as its chemical stability or interaction with other molecules, may contribute to the creation of advanced materials with unique characteristics.
Biological Activity
Competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α 4 receptor subunit (IC 50 values are 0.19 and 0.37 μ M for α 4 β 4 and α 4 β 2 receptors respectively). Antagonizes behavioral effects of nicotine in vivo .
in vitro
dhβe has been shown to be a purely competitive antagonist of the neuronal nicotinic receptor [1].
in vivo
dhβe is able to block some of the central actions of nicotine after systemic and intrathecal administration. the mechanism of blockade is different from that of mecamylamine, a classical ganglionic antagonist, and may involve a direct action of dhβe on nicotine receptor [2].
IC 50
1.3 μm for α2β2, 2.3 μm for α2β4, 0.41 μm for α3β2, 23.1 μm for α3β4, 0.37 μm for α4β2, and 0.19 μm for α4β4 [1]
references
[1] harvey sc, maddox fn, luetje cw. multiple determinants of dihydro-beta-erythroidine sensitivity on rat neuronal nicotinic receptor alpha subunits. j neurochem. 1996 nov;67(5):1953-9.[2] damaj mi, welch sp, martin br. in vivo pharmacological effects of dihydro-beta-erythroidine, a nicotinic antagonist, in mice. psychopharmacology (berl). 1995 jan;117(1):67-73.[3] murphree hb. effects in human volunteers of subparalytic doses of dihydro-beta-erythroidine. clin pharmacol ther. 1963 may-jun;4:304-10.
Check Digit Verification of cas no
The CAS Registry Mumber 29734-68-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,7,3 and 4 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 29734-68:
(7*2)+(6*9)+(5*7)+(4*3)+(3*4)+(2*6)+(1*8)=147
147 % 10 = 7
So 29734-68-7 is a valid CAS Registry Number.
