2975-41-9 Usage
Description
Indan-2-amine, also known as 2-Aminoindan or 2-Aminoindane, is an analog of amphetamine that exhibits potential bronchodilator and analgesic effects. It is characterized by the presence of an intramolecular N-H···Π hydrogen bond, which influences its conformational properties.
Uses
Used in Pharmaceutical Industry:
Indan-2-amine is used as an analgesic with sympathomimetic activity for its ability to provide pain relief and stimulate certain aspects of the sympathetic nervous system. It is particularly useful in managing various types of pain and has potential applications in the treatment of conditions that require both pain relief and stimulation of the sympathetic nervous system.
Used in Enzyme Inhibition:
Indan-2-amine is used as an inhibitor of norepinephrine methyltransferase, an enzyme involved in the metabolism of neurotransmitters. By inhibiting this enzyme, Indan-2-amine can potentially influence the levels of neurotransmitters in the body, which may have therapeutic implications for certain conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 2975-41-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,7 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2975-41:
(6*2)+(5*9)+(4*7)+(3*5)+(2*4)+(1*1)=109
109 % 10 = 9
So 2975-41-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H11N/c10-9-5-7-3-1-2-4-8(7)6-9/h1-4,9H,5-6,10H2
2975-41-9Relevant articles and documents
Synthesis of 2-indanyl urea derivatives
Takahashi,Kizu,Takaya,Maki
, p. 958 - 960 (1966)
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Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination
Du, Yi-Dan,Chen, Bi-Hong,Shu, Wei
supporting information, p. 9875 - 9880 (2021/03/29)
Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.
Preparation method of indan-2-amine
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Paragraph 0028-0033, (2019/10/01)
The invention relates to a synthetic route of indan-2-amine. 2-indanone is taken as a raw material to efficiently synthesize indan-2-amine by a one-pot method. The provided preparation method of indan-2-amine is high in yield and low in cost, is environmentally friendly, is easy to operate, and is suitable for industrialization.