2977-45-9

Basic information

• Product Name: 2,2-dimethyl-3,4-dihydronaphthalen-1-one
• Synonyms: 2,2-dimethyl-3,4-dihydronaphthalen-1-one;2,2-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one;2,2-Dimethyl-3,4-dihydronaphthalen-1(2H)-one
• CAS NO: 2977-45-9
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.23896
• Mol File: 2977-45-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 264.557°C at 760 mmHg
• Flash Point: 106.987°C
• Appearance: /
• Density: 1.018g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,2-dimethyl-3,4-dihydronaphthalen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-3,4-dihydronaphthalen-1-one(2977-45-9)
• EPA Substance Registry System: 2,2-dimethyl-3,4-dihydronaphthalen-1-one(2977-45-9)

Safety Data

• Hazardous Substances Data: 2977-45-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 47, p. 151, 1982 DOI: 10.1021/jo00340a035

InChI:InChI=1/C12H14O/c1-12(2)8-7-9-5-3-4-6-10(9)11(12)13/h3-6H,7-8H2,1-2H3

Upstream product

• 731772-68-2 2-(3-methylbut-3-en-1-yl)benzonitrile 
• 445007-06-7 4-(2-iodophenyl)-2,2-dimethylbutanenitrile 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 74-88-4 methyl iodide 

Downstream Products

• 573-98-8 dimethyl-1,2 naphtalene 
• 372967-91-4 2,2-dimethyl-1-(2-phenylethynyl-phenylethynyl)-1,2,3,4-tetrahydro-naphthalene 
• 615578-73-9 (-)-(R)-2,2-dimethyl-1,2,3,4-tetrahydronaphthalen-3-ol 
• 314041-41-3 2,2-dimethyl-1,2-dihydronaphthalenone-4-carboxylic acid (+)-menthyl ester 

Relevant articles and documents

Hydrogen Atom Transfer-Mediated Cyclisations of Nitriles

Hydrogen atom transfer-mediated intramolecular C?C coupling reactions between alkenes and nitriles, using PhSiH3 and catalytic Fe(acac)3, are described. This introduces a new strategic bond disconnection for ring-closing reactions, f

Carbopalladation of nitriles: Synthesis of benzocyclic ketones and cyclopentenones via Pd-catalyzed cyclization of ω-(2-iodoaryl)alkanenitriles and related compounds

An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)-propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functional groups. This methodology has been extended to the synthesis of tetralones and cyclopentenones.

1,1,4,7,10,10-Hexamethyltriethylenetetramine: A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides

The rate of the reaction of the lithium enolate of 1-tetralone with alkyl halides was enhanced greatly in the presence of 3 equivalents of 1,1,4,7,10,10-hexamethyltriethylenetetramine. The ratio of the monoalkylated product to the dialkylated product was found to have increased under a shorter reaction time.