298-50-0

Basic information

• Product Name: PROPARACAINE
• Synonyms: PROPARACAINE;(2-hydroxyethyl)diisopropylmethyl-ammoniuxanthene-9-carboxylate(ester);2-propanaminium,n-methyl-n-(1-methylethyl)-n-(2-((9h-xanthen-9-ylcarbonyl)oxy);propantheline;[2-[(9H-Xanthen-9-ylcarbonyl)oxy]ethyl]diisopropylmethylaminium;Diisopropylmethyl[2-(9H-xanthene-9-ylcarbonyloxy)ethyl]aminium;diisopropyl-methyl-[2-(9H-xanthene-9-carbonyloxy)ethyl]ammonium;methyl-di(propan-2-yl)-[2-(9H-xanthen-9-ylcarbonyloxy)ethyl]azanium
• CAS NO: 298-50-0
• Molecular Formula: C16H26N2O3
• Molecular Weight: 294.39
• EINECS: 206-063-2
• Mol File: 298-50-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• PKA: pKa 3.22(H2O) (Uncertain)
• CAS DataBase Reference: PROPARACAINE(CAS DataBase Reference)
• NIST Chemistry Reference: PROPARACAINE(298-50-0)
• EPA Substance Registry System: PROPARACAINE(298-50-0)

Safety Data

• Hazardous Substances Data: 298-50-0(Hazardous Substances Data)

Usage

Description

PROPARACAINE, also known as Proparacaine hydrochloride, is a colorless, water-soluble, and stable compound with a molecular formula of C13H20N2O3. It is a widely used ophthalmic anesthetic agent that belongs to the class of anticholinergic drugs. Proparacaine works by blocking the nerve impulses in the eye, providing temporary relief from discomfort and pain associated with eye conditions.

Uses

Used in Ophthalmology:
PROPARACAINE is used as a topical anesthetic for [application reason] to provide temporary relief from discomfort and pain associated with eye conditions such as corneal abrasions, foreign body removal, and diagnostic procedures.
Used in Pharmaceutical Industry:
PROPARACAINE is used as an active pharmaceutical ingredient for [application reason] to formulate eye drops and other ophthalmic solutions that help alleviate eye discomfort and pain.
Used in Veterinary Medicine:
PROPARACAINE is used as a veterinary anesthetic for [application reason] to provide temporary pain relief during diagnostic and surgical procedures in animals.
Brand Name:
PROPARACAINE is available under the brand name Pro-Banthine (Searle), which is specifically formulated for treating stomach ulcers. However, it is important to note that this brand name is associated with Propantheline, a different compound, and not directly related to PROPARACAINE.

Pharmacology

The pharmacological action of propantheline is qualitatively similar to atropine. It has a weaker effect on the CNS than atropine. Unlike atropine, it exhibits greater ganglioblocking action than antimuscarinic action. Moreover, upon overdose it causes neuromuscular curare-like blockage.

Synthesis

Propanetheline, N-methyl-N-(1-methylethyl)-N-[2-[(9H-xanthen-9- ylcarbonyl) oxy]ethyl]-2-propanaminium bromide (14.1.11), is synthesized by reacting xanthen-9-carboxylic acid chloride with 2-di-iso-propylaminoethanol, giving the ester (14.1.10), which upon reaction with methylbromide turns into the quaternary salt, propantheline (14.1.11) [12,13].

Veterinary Drugs and Treatments

Proparacaine is a rapid acting topical anesthetic useful for a variety of ophthalmic procedures including tonometry (intraocular pressure measurement), relief of corneal pain to facilitate examination, biopsy/sample collection, and to distinguish between corneal and uveal pain. Proparacaine primarily anesthetizes the cornea; with limited penetration into conjunctiva. Anesthesia is of short duration (5 – 10 minutes).

InChI:InChI=1/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H/q+1;/p-1