298-51-1

Basic information

• Product Name: 2-(diethylamino)ethyl 10H-phenothiazine-10-carboxylate hydrochloride (1:1)
• Synonyms: 10H-Phenothiazine-10-carboxylic acid, 2- (diethylamino)ethyl ester, monohydrochloride; 10H-phenothiazine-10-carboxylic acid, 2-(diethylamino)ethyl ester, hydrochloride (1:1); 10H-Phenothiazine-10-carboxylic acid, 2-(diethylamino)ethyl ester, monohydrochloride (9CI); 10-Phenothiazinecarboxylic acid, .beta.-(diethylamino)ethyl ester hydrochloride; 2-(Diethylamino)ethyl 10H-phenothiazine-10-carboxylate hydrochloride (1:1); Phenothiazine-10-carboxylic acid, 2-(diethylamino)ethyl ester, monohydrochloride (8CI)
• CAS NO: 298-51-1
• Molecular Formula: C₁₉H₂₃ClN₂O₂S
• Molecular Weight: 378.9161
• Mol File: 298-51-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 469.3°C at 760 mmHg
• Flash Point: 237.6°C
• Vapor Pressure: 5.57E-09mmHg at 25°C
• CAS DataBase Reference: 2-(diethylamino)ethyl 10H-phenothiazine-10-carboxylate hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(diethylamino)ethyl 10H-phenothiazine-10-carboxylate hydrochloride (1:1)(298-51-1)
• EPA Substance Registry System: 2-(diethylamino)ethyl 10H-phenothiazine-10-carboxylate hydrochloride (1:1)(298-51-1)

Safety Data

• Hazardous Substances Data: 298-51-1(Hazardous Substances Data)

Usage

Common Usage

Antipsychotic drug
Prescribed to manage and alleviate symptoms of mental disorders.

Medication Class

Phenothiazine
A group of medications that share similar chemical structures and therapeutic effects.

Mechanism of Action

Affects the balance of certain natural chemicals in the brain
Modulates the levels of neurotransmitters, responsible for communication between neurons, to achieve a therapeutic effect.

Prescribed Conditions

Schizophrenia, bipolar disorder, and severe behavioral problems in children
Aims to treat a range of mental and emotional conditions by regulating brain chemistry.

Administration Methods

Oral or injection
The drug can be taken either by mouth or administered through a needle injection.

Supervision

Healthcare professional
A medical expert should monitor the patient's treatment to ensure safety and effectiveness.

Potential Side Effects

May cause various side effects
Unwanted consequences may occur due to the drug's interaction with the body.

Drug Interactions

Can interact with other medications
Concurrent use with other drugs may lead to altered effects or complications.

Upstream product

• 18956-87-1 10H-phenothiazine-10-carbonyl chloride 
• 100-37-8 2-(Diethylamino)ethanol 

Relevant articles and documents

Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase

Most carbamates are pseudoirreversible inhibitors of cholinesterases. Phenothiazine carbamates exhibit this inhibition of acetylcholinesterase but produce reversible inhibition of butyrylcholinesterase, suggesting that they do not form a covalent bond with the catalytic serine. This atypical inhibition is attributable to π-π interaction of the phenothiazine moiety with F329 and Y332 in butyrylcholinesterase. These residues are in a helical segment, referred to here as the E-helix because it contains E325 of the catalytic triad. The involvement of the E-helix in phenothiazine carbamate reversible inhibition of butyrylcholinesterase is confirmed using mutants of this enzyme at A328, F329, or Y332 that show typical pseudoirreversible inhibition. Thus, in addition to various domains of the butyrylcholinesterase active site gorge, such as the peripheral anionic site and the π-cationic site of the Ω-loop, the E-helix represents a domain that could be exploited for development of specific inhibitors to treat dementias.