298-55-5

Basic information

• Product Name: Clocinizine
• Synonyms: Clocinizine;1-[(4-Chloropheny)phenylmethyl]-4-cinnamylpiperazine;1-[(4-Chlorophenyl)phenylmethyl]-4-cinnamylpiperazine;Cliocinizine;1-(4-Chlor-alpha-phenylbenzyl)-4-cinnamylpiperazin;Chlorcinnarizine;Chlorcinnazine;Clocinizina
• CAS NO: 298-55-5
• Molecular Formula: C₂₆H₂₇ClN₂
• Molecular Weight: 402.966
• Mol File: 298-55-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 534.5°Cat760mmHg
• Flash Point: 277.1°C
• Appearance: /
• Density: 1.154g/cm³
• Vapor Pressure: 1.67E-11mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: Clocinizine(CAS DataBase Reference)
• NIST Chemistry Reference: Clocinizine(298-55-5)
• EPA Substance Registry System: Clocinizine(298-55-5)

Safety Data

• Hazardous Substances Data: 298-55-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C26H27ClN2/c27-25-15-13-24(14-16-25)26(23-11-5-2-6-12-23)29-20-18-28(19-21-29)17-7-10-22-8-3-1-4-9-22/h1-16,26H,17-21H2/b10-7+

Upstream product

• 134-85-0 4-chlorobenzophenone 
• 303-26-4 N-(4-chlorobenzhydryl)piperazine 
• 4392-24-9 3-bromo-1-phenyl-1-propenyl bromide 
• 134-83-8 1-chloro-4-(chloro(phenyl)methyl)benzene 
• 119-56-2 (4-chlorophenyl)phenylmethanol 

Relevant articles and documents

Efficient synthesis of antihistamines clocinizine and chlorcyclizine

A simple and efficient route has been developed for the synthesis of anti-histamine drugs clocinizine and chlorcyclizine. The common intermediate 1-[(4-chloro phenyl) (phenyl)-methyl]-piperazine (8), is prepared from (4-chlorophenyl) (phenyl)-methanone (5), in three steps with excellent yields. All the reactions proceeded smoothly and the products were also isolated easily. Springer Science+Business Media, LLC 2011.