298197-67-8

Basic information

• Product Name: 3,5-Dioxa-2,6-disilaheptane, 2,2,6,6-tetramethyl-4-[1-[4-(2-methylpropyl)phenyl]ethylidene]-
• CAS NO: 298197-67-8
• Molecular Formula: C19H34O2Si2
• Molecular Weight: 350.649
• Mol File: 298197-67-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,5-Dioxa-2,6-disilaheptane, 2,2,6,6-tetramethyl-4-[1-[4-(2-methylpropyl)phenyl]ethylidene]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dioxa-2,6-disilaheptane, 2,2,6,6-tetramethyl-4-[1-[4-(2-methylpropyl)phenyl]ethylidene]-(298197-67-8)
• EPA Substance Registry System: 3,5-Dioxa-2,6-disilaheptane, 2,2,6,6-tetramethyl-4-[1-[4-(2-methylpropyl)phenyl]ethylidene]-(298197-67-8)

Safety Data

• Hazardous Substances Data: 298197-67-8(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 15687-27-1 ibuprofen 

Downstream Products

• 915232-06-3 (S)-ibuprofen-d 
• 51146-56-6 (S)-ibuprofen 
• 81576-55-8 (S)-(+)-methyl 2-(4-isobutylphenyl)propionate 
• 180293-49-6 2-fluoro-2-[4-(2-methylpropyl)phenyl]propionic acid 
• 51146-57-7 (R)-ibuprofene 
• 81576-57-0 (R)-ibuprofen methyl ester 

Relevant articles and documents

Synthesis of α-fluorocarboxylates from the corresponding acids using acetyl hypofluorite

α-Fluorocarboxylic esters and acids were synthesized in good yields. The corresponding esters and acids were converted to their ketene acetals, and these enol derivatives reacted with AcOF made directly from fluorine. This route circumvents the problems associated with nucleophilic fluorinations such as various eliminations and rearrangements. α- and β-branched carboxylic acid derivatives that cannot be directly fluorinated gave by this electrophilic fluorination the corresponding α-fluoro derivatives in good yield. Both the fluorination reaction and the preparation of AcOF are fast and suitable for [18]F incorporation into acids and esters needed for working with PET. α-Fluoroibuprofen (20) and methyl 2-fluoro-3,3,3-triphenylpropionate (32) are two examples of this general reaction.

Enantioselective protonation of silyl enol ethers and ketene disilyl acetals with Lewis acid-assisted chiral Bronsted acids: Reaction scope and mechanistic insights

Enantioselective protonation is a potent and efficient way to construct chiral carbons. Here we report details of the reaction using Lewis acid-assisted chiral Bronsted acids (chiral LBAs). The 1:1 coordinate complex of tin tetrachloride and optically active binaphthol ((R)- or (S)-BINOL) can directly protonate various silyl enol ethers and ketene disilyl acetals to give the corresponding α-aryl ketones and α-arylcarboxylic acids, respectively, with high enantiomeric excesses (up to 98% ee). A catalytic version of enantioselective protonation has also been achieved using stoichiometric amounts of 2,6-dimethylphenol and catalytic amounts of monomethyl ether of optically active BINOL in the presence of tin tetrachloride. This protonation is also effective for producing α-halocarbonyl compounds (up to 91% ee). DFT calculations on the B3LYP/LANL2DZ level show that the conformational structure of the chiral LBA and the orientation of activated proton on (R)-BINOLs are important for understanding the absolute stereochemistry of the products.